{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:19:12Z","timestamp":1773076752797,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T00:00:00Z","timestamp":1290902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Utility of quantitative computed tomography (QCT) for assessment of bone mineral density (BMD) in patients with thalassemia is not fully established. Majority of patients with thalassemia in India receive suboptimal iron chelation. There is paucity of data on BMD in this population. Aim was to assess BMD by lumbar QCT in adolescent patients with transfusion dependent \u03b2\u2010thalassemia major and compare with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Study was conducted prospectively, over 15 months. Single energy QCT was performed through first three lumbar vertebrae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were enrolled (age: 10\u201319 years). Thirty\u2010eight normal siblings of patients with thalassemia patients served as controls. Forty percent patients weighed &lt;3rd percentile, 64% were stunted, and 40% had suboptimal sexual maturity scores. Eighteen (40%) patients were on iron chelation with deferiprone. Mean serum ferritin was 2,800\u2009\u00b1\u20091,473\u2009ng\/ml. Mean BMD (mg\/cu\u2009mm) of cases and controls was 194.5\u2009\u00b1\u200927.1 and 170.4\u2009\u00b1\u200928.84, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002). The mean BMD of patients with ferritin &lt;2,000\u2009ng\/ml and those with a higher ferritin was 181.2\u2009\u00b1\u200914.9 and 196.7\u2009\u00b1\u200925, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.07). The finding of increased BMD in patients with thalassemia is in stark contrast to published reports. Patients had several risk factors for low BMD, including growth retardation, delayed puberty, and iron overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single energy QCT of lumbar vertebrae is not reliable for measurement of BMD in inadequately chelated patients with \u03b2\u2010thalassemia major. The deposition of iron in bone tissue may result in increased X\u2010ray attenuation values of trabecular bone. Pediatr Blood Cancer 2011;56:409\u2013412. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22912","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T13:52:33Z","timestamp":1290952353000},"page":"409-412","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative computed tomography is unreliable for measurement of bone mineral density in inadequately chelated adolescent patients with \u03b2\u2010thalassemia major: A case\u2013control study"],"prefix":"10.1002","volume":"56","author":[{"given":"Deepak","family":"Bansal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Venkateshwaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.K.","family":"Marwaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01108.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080505"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02392.x"},{"key":"e_1_2_5_5_2","first-page":"133","volume-title":"The thalassaemia syndromes","author":"Higgs DR","year":"2001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02549.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705053"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb01572.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32831ec338"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s00330-002-1676-8","article-title":"Bone densitometry in children: A critical appraisal","volume":"13","author":"van Rijn RR","year":"2003","journal-title":"Eur Radiol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10337"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.07.003"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00411.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800101300002937"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.9.1531"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb09019.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900637"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02683.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01876.x"},{"key":"e_1_2_5_21_2","first-page":"779","article-title":"Bone pain in thalassaemia: Assessment of DEXA and MRI findings","volume":"11","author":"Angastiniotis M","year":"1998","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0504-y"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1960.00270170024004"},{"key":"e_1_2_5_24_2","first-page":"127","article-title":"Study of bone density by pQCT analysis in healthy adults and patients with \u03b2\u2010thalassemia major and intermedia","volume":"6","author":"Ladis V","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000199587.76055.21"},{"key":"e_1_2_5_26_2","first-page":"307","article-title":"Bone density study at the distal radius, using pQCT analysis, in Greek thalassemic patients","volume":"2","author":"Ladis VA","year":"2004","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06527.x"}],"container-title":["Pediatric Blood &amp; 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