{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:51Z","timestamp":1788871671831,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypothyroidism remains a common late effect after irradiation of the neck\/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck\/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck\/mediastinum,\n                    <jats:sc>L<\/jats:sc>\n                    \u2010thyroxine at TSH\u2010suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8\u2010year hypothyroidism\u2010free\u2010survival after irradiation was 75\u2009\u00b1\u200915% for the former group, 0% for the latter (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL. Pediatr Blood Cancer 2011;57:166\u2013168. \u00a9 2011 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/pbc.22915","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T10:28:21Z","timestamp":1297247301000},"page":"166-168","source":"Crossref","is-referenced-by-count":5,"title":["TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma"],"prefix":"10.1002","volume":"57","author":[{"given":"Maura","family":"Massimino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Gandola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Pignoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Seregni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Marchian\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Pecori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Catania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Cefalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.4772"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.12.007"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.0195"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.028"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108293250902"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(85)90273-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950090505"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02210.x"},{"key":"e_1_2_5_11_2","first-page":"133","article-title":"Myxedema developing after lymphangiography and neck irradiation","volume":"14","author":"Rogoway WM","year":"1966","journal-title":"Clin Res"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6946"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-1-91"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(85)90283-4"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020365"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.11.3881"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903303201304"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.009"},{"key":"e_1_2_5_19_2","first-page":"526","article-title":"Thyroid iatrogenic sequelae after the treatment of pediatric cancer","volume":"53","author":"Massimino M","year":"2009","journal-title":"Q J Nucl Med Mol Imaging"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22915","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T08:32:41Z","timestamp":1700469161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7,15]]}},"alternative-id":["10.1002\/pbc.22915"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22915","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,9]]}}}