{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:13:30Z","timestamp":1790813610011,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with siblings coping with chronic illness experience stresses and disruptions in daily life as families work together to care for the affected child. Research suggests that children and adolescents with sickle cell disease (SCD) may be at risk for adjustment problems, impaired psychosocial functioning, and reduced quality of life. These potential stressors affect the child with SCD as well as their caregivers and other family members. This study examined the role of family functioning on the psychosocial functioning of healthy siblings of children with SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Participants were 65 healthy African\u2013American siblings of children with SCD with a mean age of 11.19 years (range: 7\u201316) and their primary caregiver. Caregivers completed questionnaires assessing family functioning and child adjustment including demographic surveys, the Family Relations Scale (FRS), and the Child Behavior Checklist (CBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased number of emergency room visits (\u03b2\u2009=\u2009\u22120.28, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) predicted poor psychosocial adjustment in siblings. Family functioning mediated this effect (\u03b2\u2009=\u20090.27; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). High levels of family expressiveness (total score, r\u2009=\u2009\u22120.34; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), support (total score, r\u2009=\u2009\u22120.54; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and low levels of family conflict (total score, r\u2009=\u20090.41; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were associated with improved adjustment among healthy siblings of children with SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Awareness of the possible negative psychosocial outcomes of living with a sister or a brother with SCD is important for clinicians. In particular, interventions that focus on family expressiveness, support, and conflict are indicated for this population. Pediatr Blood Cancer 2011; 57: 1055\u20131061. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22933","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T16:05:40Z","timestamp":1298736340000},"page":"1055-1061","source":"Crossref","is-referenced-by-count":23,"title":["The mediating effects of family functioning on psychosocial outcomes in healthy siblings of children with sickle cell disease"],"prefix":"10.1002","volume":"57","author":[{"given":"Jeffrey I.","family":"Gold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Treadwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Vichinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.258.9.1205"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001888-199112000-00009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm1203_6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05500.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1300\/J045v05n03_08"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2006.00591.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199305000-00009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015332828213"},{"key":"e_1_2_6_11_2","unstructured":"TreadwellM GoldJI WeissmanL BarnesM VichinskyE. Family adaptation to the diagnosis of sickle cell disease: quantitative and qualitative perspectives.1995."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/20.2.165"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050268"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/27.8.699"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-0025.1988.tb01582.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-19910901-09"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/01460869609038053"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00916356"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-198512000-00007"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/14.2.157"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.61.3.468"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-005-6667-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/25.5.287"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15326888chc2404_1"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsj002"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/24.6.491"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/28.1.59"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2008.00810.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545-5300.1985.00225.x"},{"key":"e_1_2_6_30_2","volume-title":"Family environmental scale manual","author":"Moos RH","year":"1981"},{"key":"e_1_2_6_31_2","volume-title":"FACES II: Family Adaptability and Cohesion Scales","author":"Olson DH","year":"1982"},{"key":"e_1_2_6_32_2","volume-title":"Integrative: guide for the, 1991 CBCL\/4\u201018, YSR, and TRF profiles","author":"Achenbach TM","year":"1991"},{"key":"e_1_2_6_33_2","volume-title":"Manual for the child behavior checklist\/4\u201318 and 1991 profile","author":"Achenbach TM","year":"1991"},{"key":"e_1_2_6_34_2","volume-title":"Statistical package for the social sciences [computer program], Version 8","year":"1998"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020401122858"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/27.8.711"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsm083"},{"key":"e_1_2_6_39_2","unstructured":"Starlight StarbrightTM Children's Foundation. The sickle cell slime\u2010O\u2010rama game. Available at:http:\/\/sicklecell.starlightprograms.org\/[Accessed on May 3 2007]."},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsi054"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20653"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/hsw\/31.3.209"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.2307\/351514"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/13.4.555"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.18.6.795"},{"key":"e_1_2_6_46_2","volume-title":"Manual for the social support scale for children","author":"Harter S","year":"1985"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22933","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:35:10Z","timestamp":1698748510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,25]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/pbc.22933"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22933","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,25]]}}}