{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:12:34Z","timestamp":1784128354608,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic myelogenous leukemia (CML) is caused by the <jats:italic>BCR<\/jats:italic>\u2010<jats:italic>ABL1<\/jats:italic> fusion gene that encodes for a constitutively\u2010active tyrosine kinase. Adults and children with CML are typically treated with imatinib mesylate, a BCR\u2010ABL1 tyrosine kinase inhibitor (TKI), or a second\u2010generation TKI. Several case reports have documented growth delay of unknown mechanism in children with CML treated with imatinib. We report a seven\u2010year\u2010old identical twin with CML who developed significant growth delay, as compared to her twin, during five years of TKI therapy. Detailed endocrine evaluation showed acquired growth hormone deficiency, a pathway potentially inhibited by TKIs. Pediatr Blood Cancer 2011;56:671\u2013673. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22945","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:43:21Z","timestamp":1293065001000},"page":"671-673","source":"Crossref","is-referenced-by-count":44,"title":["Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy"],"prefix":"10.1002","volume":"56","author":[{"given":"Susan L.","family":"Hobernicht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Schweiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Zeitler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"46","article-title":"Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20131995","volume":"99","author":"Ries LAG","year":"1999","journal-title":"SEER Pediatr Monogr"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0251-8"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61023-5"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3324\/haematol.2009.008359","article-title":"Longitudinal growth retardation in a prepubertal girl with chronic myeloid leukemia on long\u2010term treatment with imatinib","volume":"94","author":"Schmid H","year":"2009","journal-title":"Haematologica"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051140"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-237404"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.150"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000226288"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2006.08.003"},{"key":"e_1_2_4_11_2","first-page":"54","volume-title":"Pediatric endocrinology. 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