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There is no standard treatment defined for this disease. Here we report on eight children diagnosed with Gorham's disease at our institution over a ten\u2010year period. Soft tissue lymphangioma was present in seven and six children had splenic involvement. Disease stabilization and improvement was observed on treatment with interferon alpha\u20102b and bisphosphonate therapy. Pediatr Blood Cancer 2011;56:667\u2013670. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22948","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T23:24:50Z","timestamp":1293060290000},"page":"667-670","source":"Crossref","is-referenced-by-count":41,"title":["Gorham's disease and diffuse lymphangiomatosis in children and adolescents"],"prefix":"10.1002","volume":"56","author":[{"given":"Rajkumar","family":"Venkatramani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina S.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pisit","family":"Pitukcheewanont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio H.","family":"Malogolowkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195537050-00008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20080301-31"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.11.015"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63639-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041113"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000042235.41817.04"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200310000-00016"},{"key":"e_1_2_5_9_2","first-page":"231","article-title":"Splenic lymphangiomatosis associated with skeletal involvement (Gorham's disease): A new case and review of literature","volume":"61","author":"Barbagallo M","year":"2009","journal-title":"Minerva Pediatr"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.11.015"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1302\/0301-620X.57B2.238","article-title":"Massive osteolysis of the humerus with spontaneous recovery","volume":"57","author":"Campbell J","year":"1975","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.208"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1302\/0301-620X.58B3.956254","article-title":"Massive osteolysis complicated by chylothorax successfully treated by pleurodesis","volume":"58","author":"Patrick JH","year":"1976","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1893"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.051019"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07083"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq331"},{"key":"e_1_2_5_18_2","first-page":"693","article-title":"Platelet\u2010derived growth factor receptor\u2010\u03b2 in Gorham's disease. 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