{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:16:14Z","timestamp":1789514174100,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conflicting data exist regarding whether low bone mineral density (BMD) is associated with Fanconi anemia (FA). The current study identified the frequency of low BMD in FA, expecting low BMD even in childhood and before HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Thirty\u2010seven FA patients (18 prior HCT, 19 no prior HCT), participating in an IRB\u2010approved database, had clinical assessment of DXA of lumbar spine BMD. Four had used androgens, one later underwent HCT. Most had used glucocorticoids after HCT (prolonged in five), and one more with no HCT. BMD [in standard deviation units from mean for age (SD), gender, and ethnicity (BMD <jats:italic>Z<\/jats:italic>\u2010score)] was then adjusted for height age, and separately for bone maturation (BA). Data were collected for height SD, pubertal stage, and duration since HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMD <jats:italic>Z<\/jats:italic>\u2010score (without adjustment) was &lt;\u22121 SD in half of FA children. BA\u2010adjusted BMD <jats:italic>Z<\/jats:italic>\u2010score was similar. (BA was not usually delayed, although most patients were short.) In contrast, height age\u2010adjusted BMD <jats:italic>Z<\/jats:italic>\u2010score was normal in most with FA (only below \u22122.0 in one child after prolonged glucocorticoids). Mean duration after HCT until DXA test was 6.2 years (median 4.2 years, range 1\u201318 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children and adolescents with FA have normal BMD prior to and after HCT, when DXA results are adjusted for bone size\/height age. In contrast, BA\u2010adjustment of BMD was not useful in this population. Individual BMD results may be influenced by gonadal function, transplantation status, and prolonged glucocorticoid therapy. Pediatr Blood Cancer 2011; 57: 1034\u20131038. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22956","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T02:04:38Z","timestamp":1302228278000},"page":"1034-1038","source":"Crossref","is-referenced-by-count":10,"title":["Bone mineral density is normal in children with Fanconi anemia"],"prefix":"10.1002","volume":"57","author":[{"given":"Susan R.","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan 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