{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:38:28Z","timestamp":1782488308247,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe pandemic influenza A (H1N1) infection can lead to acute respiratory failure (ARF) with associated high mortality. Children with malignancy may be at higher risk of H1N1\u2010associated ARF because of underlying primary disease or immunosuppression associated with chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We describe the clinical course and outcome of critically ill pediatric oncology\/hematology patients with H1N1\u2010associated ARF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients were admitted to the St. Jude Children's Research Hospital (SJCRH) ICU with H1N1 infection during the 2009\u20132010 influenza season. Underlying diagnoses included 2 patients with acute lymphoblastic leukemia and one each with neuroblastoma, brainstem glioma, and hemolytic anemia secondary to pyruvate kinase deficiency. All patients were mechanically ventilated secondary to ARF following unsuccessful trials of non\u2010invasive ventilatory support. The majority of patients (4\/5) required inotropic support, and none required dialysis. Further measures to support their ARF included high frequency oscillatory ventilation in 2 patients, nitric oxide in 3 patients, and surfactant in 1 patient. Three patients had bronchopleural air leak. All patients received oseltamivir; however, 2 were switched to intravenous zanamivir once resistance to oseltamivir was documented. Mean duration of mechanical ventilation was 24\u2009\u00b1\u20096.8 days and mean duration of ICU admission was 37\u2009\u00b1\u200912 days. All patients survived to hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our series suggests an overall favorable outcome in immunocompromised children with H1N1\u2010related ARF. Our experience underscores the value of aggressive support during H1N1\u2010related ARF, and early detection and management of oseltamivir\u2010resistant H1N1 infection in this high\u2010risk population. Pediatr Blood Cancer 2011; 57: 625\u2013628. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22973","type":"journal-article","created":{"date-parts":[[2011,2,5]],"date-time":"2011-02-05T08:54:52Z","timestamp":1296896092000},"page":"625-628","source":"Crossref","is-referenced-by-count":15,"title":["Severe H1N1\u2010associated acute respiratory failure in immunocompromised children"],"prefix":"10.1002","volume":"57","author":[{"given":"Lama","family":"Elbahlawan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya H.","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Furman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Jeha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Ray","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181ccedae"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2517"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8044"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.11.004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1536"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.01.009"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.8889"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0464-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0910893"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.12.012"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/201001-0037OC"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1496"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8927"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq254"},{"key":"e_1_2_5_16_2","article-title":"Novel H1N1 influenza in hematopoietic stem cell transplantation recipients: Two centers' experiences","author":"Espinosa\u2010Aguilar L","year":"2010","journal-title":"Biol Blood Marrow Tranplant"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22619"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"19536","DOI":"10.2807\/ese.15.14.19536-en","article-title":"The emergence of oseltamivir\u2010resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November\u2013December, 2009","volume":"15","author":"Harvala H","year":"2010","journal-title":"Euro Surveill"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61528-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1607.091691"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1727-6"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22973","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22973","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T12:58:35Z","timestamp":1700485115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/pbc.22973"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22973","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,4]]}}}