{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:34:17Z","timestamp":1773261257322,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pirarubicin (tetrahydropyranyl\u2010adriamycin: THP) is a derivative of doxorubicin with reportedly less cardiotoxicity in adults. However no studies of cardiotoxicity in children treated with THP have been reported. This study was performed to assess the THP\u2010induced cardiotoxicity for children with acute lymphoblastic leukemia (ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This study comprised 61 asymptomatic patients aged from 7.6 to 25.7 years old. Median follow\u2010up time after completion of anthracycline treatment was 8.1 years (range: 1.7\u201312.5). The cumulative dose of THP ranged from 120 to 740\u2009mg\/m<jats:sup>2<\/jats:sup> with a median of 180\u2009mg\/m<jats:sup>2<\/jats:sup>. Patients underwent electrocardiogram (ECG), echocardiography, the 6\u2010min walk test (6MWT), and measurements of serum brain natriuretic peptide (BNP) before and after exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects showed normal left ventricular function assessed by echocardiography. Ventricular premature contraction in Holter ECG and reduced exercise tolerance in the 6MWT were detected in 2\/46 (3.3%) and 5\/41(12.2%), respectively. Abnormal BNP levels were detected in 6\/60 (10%) both before and after exercise. The cumulative dose of THP was significantly correlated with BNP levels after exercise (r\u2009=\u20090.27, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), but not with any other cardiac measurements. Further analysis revealed that subjects with a high cumulative dose \u2267300\u2009mg\/m<jats:sup>2<\/jats:sup> had significantly higher BNP levels after exercise compared with subjects with a low cumulative dose &lt;300\u2009mg\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant cardiac dysfunction was detected in long\u2010term survivors who received THP treatment. The use of post\u2010exercise BNP level to indicate high cardiotoxicity risk should be verified by further study. Pediatr Blood Cancer 2011; 57: 461\u2013466. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23012","type":"journal-article","created":{"date-parts":[[2011,2,5]],"date-time":"2011-02-05T08:55:24Z","timestamp":1296896124000},"page":"461-466","source":"Crossref","is-referenced-by-count":20,"title":["Assessment of late cardiotoxicity of pirarubicin (THP) in children with acute lymphoblastic 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