{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:39:03Z","timestamp":1789915143593,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute, Bethesda, MD","award":["U24 CA55727"],"award-info":[{"award-number":["U24 CA55727"]}]},{"name":"Children's Cancer Research Fund and the American Lebanese Syrian Associated Charities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies have found associations between cancer therapies and auditory complications, but data are limited on long\u2010term outcomes and risks associated with multiple exposures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The Childhood Cancer Survivor Study is a retrospective cohort investigating health outcomes of long\u2010term survivors (5+ years) diagnosed and treated between 1970 and 1986 compared to a randomly selected sibling cohort. Questionnaires were completed by 14,358 survivors of childhood cancer and 4,023 sibling controls. Analysis determined the first occurrence of four auditory conditions in two time periods: diagnosis to 5 years post\u2010diagnosis, and \u22655 years post\u2010diagnosis. Multivariable analyses determined the relative risks (RR) and 95% confidence interval (CI) of auditory conditions by treatment exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five or more years from cancer diagnosis, survivors were at increased risk of problems hearing sounds (RR\u2009=\u20092.3; 95% CI: 1.8\u20132.8), tinnitus (RR\u2009=\u20091.7; 95% CI: 1.4\u20132.1), hearing loss requiring an aid (RR\u2009=\u20094.4; 95% CI: 2.8\u20136.9), and hearing loss in 1 or both ears not corrected by a hearing aid (RR\u2009=\u20095.2; 95% CI: 2.8\u20139.5), when compared to siblings. Temporal lobe and posterior fossa radiation was associated with these outcomes in a dose\u2010dependent fashion. Exposure to platinum compounds was associated with an increased risk of problems hearing sounds (RR\u2009=\u20092.1; 95% CI: 1.3\u20133.2), tinnitus (RR\u2009=\u20092.8; 95% CI: 1.9\u20134.2), and hearing loss requiring an aid (RR\u2009=\u20094.1; 95% CI: 2.5\u20136.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood cancer survivors are at risk of developing auditory complications. Radiation and platinum compounds are determinants of this risk. Follow\u2010up is needed to evaluate the impact of auditory conditions on quality of life. 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