{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:18:04Z","timestamp":1760908684172},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, no effective curative option is available for children with neuroblastoma (NB) who failed tandem high\u2010dose chemotherapy and autologous stem cell transplantation (HDCT\/autoSCT). The present study evaluated the feasibility and efficacy of reduced\u2010intensity allogeneic stem cell transplantation (RI alloSCT) in six children with NB who failed tandem HDCT\/autoSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A cyclophosphamide\/fludarabine regimen was used as a conditioning for HLA\u2010matched SCT, and ATG was added for haploidentical SCT. Peripheral blood stem cells from four HLA\u2010matched donors and two haploidentical donors were transplanted. Immune suppression was rapidly tapered if graft\u2010versus\u2010host disease (GVHD) was absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regimen\u2010related short\u2010term toxicity was manageable, and complete donor chimerism was achieved in the early period after transplant. Grade I\/II acute GVHD developed or was induced in all patients. Tumor response, attributed to a graft\u2010versus\u2010tumor (GVT) effect, was observed in two of six patients after induction of acute GVHD. The other four patients with significant tumor burden prior to transplant had tumor progression despite presence of GVHD. However, it was difficult to effectively reduce the tumor burden prior to transplant through the use of conventional treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although regimen\u2010related short\u2010term toxicity was manageable in intensively pretreated patients with NB, GVT effect was not sufficiently strong to control tumor progression in patients who had a significant tumor burden at transplant. Therefore, new treatment modalities to effectively reduce tumor burden prior to transplant in concert with post\u2010transplant adjuvant treatment to enhance the GVT effect are needed to improve the outcome after RI alloSCT. Pediatr Blood Cancer 2011; 57: 660\u2013665. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23035","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:25Z","timestamp":1308339865000},"page":"660-665","source":"Crossref","is-referenced-by-count":23,"title":["Reduced\u2010intensity allogeneic stem cell transplantation for children with neuroblastoma who failed tandem autologous stem cell transplantation"],"prefix":"10.1002","volume":"57","author":[{"given":"Ki Woong","family":"Sung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Won","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keon Hee","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Hoe","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Youn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Joo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411601"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70291-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6986"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.13.2567"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.060"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705691"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.10.3221"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.5016"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00324-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077251"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2236"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704070"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-942256"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705681"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000225780.90991.49"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(00)70009-7"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700614"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700989"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431101"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1022"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.279"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90380-0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26616-X_12"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.11.2382"},{"key":"e_1_2_6_27_2","first-page":"37","article-title":"Comparison of auto versus allografting as consolidation of primary treatments in advanced neuroblastoma over one year of age at diagnosis: Report from the European Group for Bone Marrow Transplantation","volume":"14","author":"Ladenstein R","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.08.124"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6400"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21126"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.05.007"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2000"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911123"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702996"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.285"}],"container-title":["Pediatric Blood &amp; 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