{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:14:55Z","timestamp":1793344495182,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union Framework 6 Integrated Project eTumour","award":["FP6-2002-LIFESCIHEALTH 503094"],"award-info":[{"award-number":["FP6-2002-LIFESCIHEALTH 503094"]}]},{"name":"Medical Research Council","award":["G0601327"],"award-info":[{"award-number":["G0601327"]}]},{"name":"Department of Health National Clinician Scientist Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance spectroscopy (MRS) has been successful in characterising a range of brain tumours and is a useful aid to non\u2010invasive diagnosis. The pineal region poses considerable surgical challenges and a major surgical resection is not required in the management of all tumours. Improved non\u2010invasive assessment of pineal region tumours would be of considerable benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single voxel MRS (TE 30\u2009ms, TR 1500, 1.5\u2009T) was performed on 15 pineal tumours: 5 germinomas, 1 non\u2010germinomatous secreting germ cell tumour (GCT), 2 teratomas, 5 pineoblastomas, 1 pineal parenchymal tumour (PPT) of intermediate differentiation and 1 pineocytoma. Two germinomas outside the pineal gland were also studied. Metabolite, lipid and macromolecule concentrations were determined with LCModel\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Germ cell tumours had significantly higher lipid and macromolecule concentrations than other tumours (<jats:italic>t<\/jats:italic>\u2010test; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The teratomas had significantly lower total choline and creatine levels than germinomas (z test; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Taurine was convincingly detected in germinomas as well as PPTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Magnetic resonance spectroscopy is useful for characterising pineal region tumours, aiding the non\u2010invasive diagnosis and giving additional biological insight. Pediatr Blood Cancer 2011; 57: 972\u2013977. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23044","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T17:59:53Z","timestamp":1311703193000},"page":"972-977","source":"Crossref","is-referenced-by-count":20,"title":["Short echo time single voxel 1H magnetic resonance spectroscopy in the diagnosis and characterisation of pineal tumours in children"],"prefix":"10.1002","volume":"57","author":[{"given":"Lisa M.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel 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