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Many potential adverse sequelae associated with granulocyte transfusions are well recognized, including febrile reactions, fluid overload, alloimmunization, and lung injury. Other potential adverse sequelae, however, are less well known. This case report describes an infant with familial hemophagocytic lymphohistiocytosis who developed polycythemia (hemoglobin 10\u201317.6\u2009g\/dl) following four daily transfusions of 20\u2009ml\/kg of apheresis collected, steroid stimulated donor granulocytes. Expanded knowledge of potential risks of transfused granulocytes will allow for rapid recognition of transfusion\u2010related complications, should they occur. Pediatr Blood Cancer 2011; 57: 1236\u20131238. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.23080","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T05:01:49Z","timestamp":1299128509000},"page":"1236-1238","source":"Crossref","is-referenced-by-count":0,"title":["Polycythemia in an infant secondary to granulocyte transfusions"],"prefix":"10.1002","volume":"57","author":[{"given":"Olufolake","family":"Adisa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney K.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard M.","family":"Katzenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.07.018"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005341.pub2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06996.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1981.tb01003.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-002-0394-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0041-x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.11.3302"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41081037.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02576.x"},{"key":"e_1_2_5_11_2","volume-title":"Standards for Blood Banks and Transfusion Services","year":"2008"},{"key":"e_1_2_5_12_2","volume-title":"Technical Manual","author":"Roback J","year":"2008"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1182\/blood.V57.1.90.90","article-title":"Concomitant administration of granulocyte transfusions and amphotericin B in neutropenic patients: Absence of significant pulmonary toxicity","volume":"57","author":"Dana BW","year":"1981","journal-title":"Blood"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830310206"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000460849","article-title":"Pulmonary complications during granulocyte transfusions: Incidence and clinical features","volume":"42","author":"Karp DD","year":"1982","journal-title":"Vox Sang"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2000.79100591.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(1996)11:1<1::AID-JCA1>3.0.CO;2-F"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01619.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318196a6f9"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:17:59Z","timestamp":1696857479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,2]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,12,15]]}},"alternative-id":["10.1002\/pbc.23080"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23080","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,2]]}}}