{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:37:15Z","timestamp":1789810635631,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine and list the clinical and pathological features of cutaneous hematologic diseases in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We retrospectively analyzed the data for 51 patients up to 15 years of age, who presented with primary cutaneous hematologic disorders according to the WHO\u2010EORTC classification, at Necker\u2010Enfants Malades Hospital, Paris, France, over a 17\u2010year period. The cases were classified into the following diagnostic categories: CD30+ T\u2010cell lymphoproliferative disorders (24) all consisting of lymphomatoid papulosis (LyP, 24), lymphoblastic lymphoma (LL, 7), acute leukemias (AL, 7), mycosis fungoides (MF, 5), Epstein\u2013Barr virus\u2010related lymphoproliferative disorders (EBV\u2010related LPD, 5), T\/NK\u2010cell lymphoma, nasal type (1), \u03b3\/\u03b4 T\u2010cell lymphoma (1), and panniculitis\u2010like T\u2010cell lymphoma (1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We encountered a majority of LyP. No secondary lymphoma was found in LyP patients with a median follow\u2010up of 8 years. 29% and 80% of LyP and MF patients, respectively, presented with pityriasis lichenoides chronica (PLC) before onset of disease. Owing to a frequently misleading clinicopathological presentation, MF patients were first underdiagnosed. Clinicopathological features of LL and AL were highly stereotypical, leading to the diagnosis being suspected and confirmed more promptly. In the latter patients and in EBV\u2010related LPD patients, skin lesions usually led to the discovery of systemic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distribution of cutaneous hematologic diseases seems to be different in adults and in children aged &lt;15\u2010year old. PLC was strongly correlated with MF and LyP. Physicians must be made aware of the stereotypical clinical presentations of LL and AL to allow prompt diagnosis and treatment. Pediatr Blood Cancer 2012; 58: 226\u2013232. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23103","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T21:11:27Z","timestamp":1301346687000},"page":"226-232","source":"Crossref","is-referenced-by-count":74,"title":["Cutaneous hematologic disorders in children"],"prefix":"10.1002","volume":"58","author":[{"given":"Olivia","family":"Boccara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Blanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"de 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