{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:40Z","timestamp":1761101080176},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Veno\u2010occlusive disease (VOD) is a major complication following hematopoietic stem cell transplantation (HSCT). Its diagnosis is based on clinical criteria, which have a limited sensitivity. Increased plasminogen activator inhibitor\u20101 (PAI\u20101) levels have been suggested as a marker of VOD. We aimed to prospectively evaluate how the fibrinolytic parameters behaved to discriminate VOD from other liver disorders occurring after HSCT in a pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A total of 195 HSCT were performed on 161 children and VOD complicated 11 cases (6.8%). Alanine aminotransferase, total bilirubin, PAI\u20101 antigen (PAI\u20101:Ag) and activity, t\u2010PA antigen, D\u2010dimer, prothrombin time, activated partial thromboplastin time, antithrombin, fibrinogen, and platelet counts were measured in 105 HSCT before and then weekly for 1 month after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An early, significant increase in the fibrinolytic parameters was seen in patients who developed VOD, even before VOD was diagnosed clinically, by comparison with patients without complications or those with non\u2010VOD liver disorders. The combined increase in bilirubin, D\u2010dimer, and PAI\u20101:Ag levels beyond the normal range distinguished VOD cases from other liver complications with a high sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that fibrinolytic tests can help diagnose VOD after HSCT in the pediatric population. Pediatr Blood Cancer 2012; 58: 791\u2013797. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23213","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T08:54:16Z","timestamp":1308128056000},"page":"791-797","source":"Crossref","is-referenced-by-count":18,"title":["Contribution of fibrinolytic tests to the differential diagnosis of veno\u2010occlusive disease complicating pediatric hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"58","author":[{"given":"Maria 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