{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:29:55Z","timestamp":1700612995823},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T00:00:00Z","timestamp":1310515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CNS involvement in Hemophagocytic Lymphohistiocytosis (HLH) has been reported in 63\u201373% of children at diagnosis [Haddad et al. (1997); Blood 89: 794\u2013800; Horne et al. (2008); Br J Haematol 140: 327\u2013335]. Patients can present with neurologic symptoms, abnormal CSF cytology, abnormal neuro\u2010imaging, or a combination of these findings. CNS involvement is usually associated with a poor prognosis and increased mortality. The 3 year overall survival is 44% in patients with CNS involvement compared to 67% in patients without CNS involvement at diagnosis [Horne et al. (2008); Br J Haematol 140: 327\u2013335]. We describe a treatment strategy employing systemic dexamethasone to control CNS disease in a patient with familial HLH and persistent CNS disease post Bone Marrow Transplant. Pediatr Blood Cancer 2012; 59: 189\u2013190. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.23248","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T19:28:49Z","timestamp":1310585329000},"page":"189-190","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of recurrent CNS disease post\u2010bone marrow transplant in familial HLH"],"prefix":"10.1002","volume":"59","author":[{"given":"Hemalatha G.","family":"Rangarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darci","family":"Grochowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mollie F.","family":"Mulberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Gheorghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce M.","family":"Camitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie\u2010An M.","family":"Talano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.794"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06922.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.82"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07315.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40732"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-282392"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22310"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22239"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1789"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70190-8"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2007.8.1.78"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0569-z"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200106000-00021"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.133"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:20:29Z","timestamp":1700594429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,13]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7,15]]}},"alternative-id":["10.1002\/pbc.23248"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23248","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,13]]}}}