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Elevation of serum beta hCG and hypercalcemia with detection of PTHrP was associated with tumor progression. The tumor was refractory to multiagent chemotherapy, and the patient died of the disease at 22 months of age. This case is novel in demonstrating a beta hCG secreting refractory NRSTS. Pediatr Blood Cancer 2011; 57: 1244\u20131246. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.23271","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T15:17:42Z","timestamp":1314976662000},"page":"1244-1246","source":"Crossref","is-referenced-by-count":7,"title":["Refractory pediatric nonrhabdomyosarcoma soft tissue sarcoma associated with ectopic production of beta hCG and hypercalcemia induced by PTHrP"],"prefix":"10.1002","volume":"57","author":[{"given":"Nami","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Hamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.016"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21412"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.02.019"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.5.1268"},{"key":"e_1_2_4_6_2","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1200\/JCO.2001.19.12.3091","article-title":"Intergroup rhabdomyosarcoma study\u2010IV: Results for patients with nonmetastatic disease","volume":"15","author":"Crist WM","year":"2001","journal-title":"J Clin Oncol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90126-4"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90337-2"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01639.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830501)51:9<1647::AID-CNCR2820510916>3.0.CO;2-0"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2008.21.3.275"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860701)58:1<131::AID-CNCR2820580123>3.0.CO;2-9"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200208000-00010"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.106.000224"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/658090"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02768213"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420306"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930701)72:1<256::AID-CNCR2820720145>3.0.CO;2-D"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1090"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199807000-00009"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24471"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23271","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:18:03Z","timestamp":1696857483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,2]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,12,15]]}},"alternative-id":["10.1002\/pbc.23271"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23271","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,2]]}}}