{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:34:54Z","timestamp":1781220894189,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T00:00:00Z","timestamp":1314576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood cancer survivors are at high risk for reduced bone mineral density (BMD). Our objective was to determine whether post\u2010pubertal adolescent survivors of brain tumors, whose tumor or treatments placed them at risk for pituitary hormone deficiencies, have low BMD near time of peak bone mass accrual, and to assess risk factors for decreased BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Chart review of 36 post\u2010pubertal adolescents with history of tumor or radiation therapy (RT) of the hypothalamic\u2013pituitary area who had undergone BMD screening via dual\u2010energy X\u2010ray absorptiometry (DXA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age at DXA was 16.9\u2009\u00b1\u20091.9 years (mean\u2009\u00b1\u2009SD). Time since diagnosis was 8.5\u2009\u00b1\u20093.6 years. Median BMD <jats:italic>Z<\/jats:italic> scores were \u20130.95 (range \u22122.7 to 1.7) at the femoral neck, \u22121.20 (\u22123.6 to 1.8) at the hip, and \u22120.90 (\u22123.7 to 1.8) at the spine. Bone mineral apparent density (BMAD) <jats:italic>Z<\/jats:italic> scores were \u22120.23 (\u22122.7 to 1.9) at the femoral neck and \u22120.45 (\u22123.0 to 2.3) at the spine. Those with history of \u22651 fracture had lower BMD <jats:italic>Z<\/jats:italic> scores of the femoral neck, total hip, and spine (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Those with treated GH deficiency (GHD) had a higher BMD <jats:italic>Z<\/jats:italic>\u2010score at the femoral neck, total hip, and spine (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than those not treated. There was no difference in BMD with respect to treatment with chemotherapy, cranial or spinal RT, or hypogonadism. Spontaneous menarche and regular periods did not correlate with BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In post\u2010pubertal adolescent survivors of childhood brain tumors, fracture history and untreated GHD are risk factors for decreased BMD. Pediatr Blood Cancer 2012; 58: 959\u2013963. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23300","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T04:41:23Z","timestamp":1314852083000},"page":"959-963","source":"Crossref","is-referenced-by-count":37,"title":["Bone density in post\u2010pubertal adolescent survivors of childhood brain tumors"],"prefix":"10.1002","volume":"58","author":[{"given":"Laurie E.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua H.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Y.","family":"Popovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina N.","family":"Sainath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry 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