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Splenic involvement is an indicator of poor prognosis, with spleen size its surrogate marker in evaluation and scoring. We describe a case of pediatric LCH with progressive splenomegaly despite treatment, which when examined at splenectomy revealed no LCH involvement but extramedullary hematopoiesis. These findings thus challenge our understanding of splenomegaly as a marker of disease. Pediatr Blood Cancer 2012; 58: 998\u2013999. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.23313","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T19:35:02Z","timestamp":1316115302000},"page":"998-999","source":"Crossref","is-referenced-by-count":2,"title":["Splenomegaly unresponsive to standard and salvage chemotherapy in Langerhans cell histiocytosis: A case of extramedullary hematopoiesis"],"prefix":"10.1002","volume":"58","author":[{"given":"Ellen C.","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcine","family":"Ellwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,15]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.02.012"},{"key":"e_1_2_4_3_2","first-page":"213","volume-title":"Hematology\/oncology clinics of North America: Langerhans cell histiocytosis","author":"Lampert F","year":"1998"},{"key":"e_1_2_4_4_2","first-page":"327","volume-title":"Hematology\/oncology clinics of North America: Langerhans cell histiocytosis","author":"Broadbdent V","year":"1998"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20364"},{"key":"e_1_2_4_6_2","first-page":"57","article-title":"Prognostic factors in histiocytosis X","volume":"3","author":"Lahey ME","year":"1981","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199605)26:5<334::AID-MPO6>3.0.CO;2-J"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21498"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170527"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20160"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9667"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21782"},{"key":"e_1_2_4_13_2","volume-title":"Rudolph's Pediatrics","author":"Pearson HA","year":"2003"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950110307"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.2350\/09-05-0651-OA.1"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21227"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:55:25Z","timestamp":1696931725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/pbc.23313"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23313","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,15]]}}}