{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:39:51Z","timestamp":1790174391843,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue (MALT) lymphoma comprises approximately 8% of all non\u2010Hodgkin lymphomas and is the most common lymphoma in the gastro\u2010intestinal tract. It is caused by genetic abnormalities or bacterial infections\/chronic inflammation. B\u2010cell lymphoma\/leukemia 10 (BCL10) overexpression and nuclear expression have been associated with high\u2010grade MALT lymphomas with genetic abnormalities that are unresponsive to <jats:italic>Helicobacter pylori<\/jats:italic> eradication treatment. To explore the molecular mechanism of BCL10 overexpression on the pathogenesis and malignant phenotype of MALT lymphoma, we generated E\u00b5SR\u2010BCL10 transgenic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>By generation of heterozygous and homozygous EuSR\u2010BCL10 mice and showing BCL10 expression levels in these mice, we quantitatively examined relation of MZ B cell expansion and inhibition of caspase\u20108 activity with BCL10 protein level. We also investigated API2 and caspase\u20108 expression by Western blot and their interaction with BCL10 by co\u2010immunoprecipitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MZ B\u2010cell expansion is directly related to BCL10 protein level in a dose\u2010dependent manner. The activity of caspases\u20108 and \u20103, but not caspase\u20109, was inhibited with increasing of BCL10 protein level. Expanded MZ B cells showed selective survival under stimulation of anti\u2010immunoglobulin M, but not dexamethasone, \u03b3\u2010irradiation, or anti\u2010CD95, implying that overexpressed BCL10 exerts anti\u2010apoptotic effects through B\u2010cell antigen receptor (BCR) pathway. Overexpressed BCL10 protein co\u2010immunoprecipitated with caspase\u20108 and API2 protein, suggesting an in vivo interaction of them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate a novel effect of overexpressed BCL10 in the pathogenesis of high\u2010grade MALT lymphoma by increasing expression of API2 and it then forming a protein complex with BCL10\/caspase\u20108 leading to caspase\u20108 activity suppression. Pediatr Blood Cancer 2012; 58: 865\u2013871. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23331","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T23:43:58Z","timestamp":1317167038000},"page":"865-871","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of caspase\u20108 activity caused by overexpression of bcl10 contributes to the pathogenesis of high\u2010grade MALT lymphoma"],"prefix":"10.1002","volume":"58","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan W.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quangeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.47.31"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27476"},{"key":"e_1_2_6_4_2","first-page":"3944","article-title":"The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low\u2010grade but not high grade malignant non\u2010Hodgkin's lymphomas of the mucosa\u2010associated lymphoid tissue (MALT) type","volume":"57","author":"Ott G","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3601"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/8767"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2963"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3236"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403644"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403813"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20278"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64630-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1182"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.081117"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.087"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03699.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-025809"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4590"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-192583"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800597"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni963"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1248"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1680"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-6059-6"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00189-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104765"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110902"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.09.033"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01043-8"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003004"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25641"}],"container-title":["Pediatric Blood &amp; 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