{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:06:45Z","timestamp":1791209205064,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent discoveries of processes that govern regulation of body weight and energy expenditure have led to development of new anti\u2010obesity pharmacological agents. This article will inform health professionals of new anti\u2010obesity medications that target neuronal systems within the central nervous system (CNS) and peripheral humoral proteins that send signals to the CNS. An emerging theme of new therapies is to use combination medications that are directed toward several targets or leverage existing gastrointestinal satiety hormonal signals. By using combination therapies, it is anticipated that greater weight loss will be achieved compared to monotherapy. Pediatr Blood Cancer 2012; 58: 140\u2013143. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.23366","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T18:12:35Z","timestamp":1318961555000},"page":"140-143","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacologic management of obesity"],"prefix":"10.1002","volume":"58","author":[{"given":"Robert F.","family":"Kushner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"issue":"2","key":"e_1_2_7_2_2","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report","volume":"6","author":"National Heart, Lung, and Blood Institute (NHLBI) and National Institute for Diabetes and Digestive and Kidney Diseases (NIDDKD)","year":"1998","journal-title":"Obes Res"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980521l"},{"key":"e_1_2_7_4_2","volume-title":"Pharmacological and surgical treatment of obesity. Summary evidence report\/technology assessment no. 103. AHRQ publication no. 04\u2010E028\u20101","author":"Shekelle PG","year":"2004"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.994"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003114"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19412"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2004.00125.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60033-6"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39385.413113.25"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.05.048"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69705-5"},{"key":"e_1_2_7_13_2","first-page":"1","article-title":"Emerging role of GLP\u20101 receptor agonists in the treatment of obesity","volume":"3","author":"Neff LM","year":"2010","journal-title":"Diabetes Metab Obes Targets Ther"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1267"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4382"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1083"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2390"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61375-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1732-4"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.626"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2003"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.184"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708283370901"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.17.2071"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.13.1703"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1321"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.15.3.257"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.01.036"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1124\/mi.5.5.8"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909809"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100163"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03442-5"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.86"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60888-4"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802783"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.206"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23366","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:58:16Z","timestamp":1696935496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,18]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/pbc.23366"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23366","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,18]]}}}