{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:13Z","timestamp":1788871573050,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health Pediatric Oncology Clinical Research Training Grant","award":["CA090433-06"],"award-info":[{"award-number":["CA090433-06"]}]},{"name":"Kurt Groten Family Research Scholars' Program"},{"name":"St. Baldrick's Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Children with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non\u2010DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0005); longer hospitalizations (HR 1.4,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001); and more frequent microbiologically documented infections (HR 5.7,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0019), mucositis (HR 29.0,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0006), and cellulitis (HR 3.0,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.033). Severe neutropenia, monocytopenia, and increased cellulitis in DS\u2010ALL suggest the importance of skin hygiene, vigilance and aggressive treatment of cutaneous infections. Pediatr Blood Cancer 2012; 58: 633\u2013635. \u00a9 2011 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/pbc.23371","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T09:42:27Z","timestamp":1321868547000},"page":"633-635","source":"Crossref","is-referenced-by-count":13,"title":["Myelosuppression and infectious complications in children with down syndrome and acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"58","author":[{"given":"Karen R.","family":"Rabin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Kozinetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0217"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06337.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"256a","DOI":"10.1182\/blood.V106.11.873.873","article-title":"Acute lymphoblastic leukaemia has a poor outcome in children with Down Syndrome due to infective death in remission (results of UK MRC ALL 97 trial)","volume":"106","author":"de la Fuente J","year":"2005","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1865a","DOI":"10.1182\/blood.V108.11.1865.1865","article-title":"Increased infection\u2010related mortality for children with Down syndrome in contemporary Children's Oncology Group acute lymphoblastic leukemia clinical trials","volume":"108","author":"Maloney KW","year":"2006","journal-title":"Blood"},{"key":"e_1_2_6_6_2","unstructured":"Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE).2003."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.07.022"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00459.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03890.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb04318.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23168"},{"key":"e_1_2_6_13_2","article-title":"Absolute lymphocyte counts refine minimal residual disease\u2010based risk stratification in childhood acute lymphoblastic leukemia","author":"Rabin KR","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80131-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00444952"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20092"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.07.011"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21737"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181aa6eae"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.060"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000065859"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/524736"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.23371","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.23371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:35:11Z","timestamp":1697618111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.23371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/pbc.23371"],"URL":"https:\/\/doi.org\/10.1002\/pbc.23371","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}