{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:42:19Z","timestamp":1790174539829,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High satisfaction with iron chelation is a major determinant for adherence to ICT in beta\u2010thalassaemia major (\u03b2\u2010TM) patients. In this study, a new tool to assess different domains of satisfaction for available forms of ICT was developed and validated. The impact of patients' satisfaction with ICT has been tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Items were generated via focus groups and a preliminary version with 24 items (ICT\u2010Sat) with an additional item for treatment preference and a knowledge questionnaire (KQ) was developed. 170 \u03b2\u2010TM patients from three Thalassaemia centers in Egypt, aged 2\u201332 years received three questionnaires to fill in; the new ICT\u2010Sat, a KQ, and a previously validated tool for satisfaction with ICT (SICT) and retested 4\u20136 weeks later to ensure re\u2010test reliability. Type of chelation, drug related adverse events, compliance with ICT, and serum ferritin level (SF) during the year prior to the study as well as available cardiac T2*data were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty two \u03b2\u2010TM patients completed all questionnaires; median age was 12 years. The final 15 remaining ICT\u2010Sat items, yielding to four domain scores, explained 70.6% of the total variance. The \u201cperceived effectiveness\u201d and \u201cfear and worries\u201d domains of the ICT\u2010Sat correlated significantly with the domains \u201cperceived effectiveness\u201d and \u201cacceptance\u201d of the SICT. Patients treated with oral ICT were more satisfied with perceived effectiveness, and their side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A new clinically based ICT\u2010Sat tool was developed and revealed good psychometric characteristics. Adherence to ICT was better correlated with \u201cperceived effectiveness\u201d and SF level. Pediatr Blood Cancer 2012; 58: 910\u2013915. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.23413","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T19:40:34Z","timestamp":1326138034000},"page":"910-915","source":"Crossref","is-referenced-by-count":8,"title":["A new tool for the assessment of satisfaction with iron chelation therapy (ICT\u2010Sat) for patients with \u03b2\u2010thalassemia major"],"prefix":"10.1002","volume":"58","author":[{"given":"Mohsen S.","family":"Elalfy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Massoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayera H.","family":"Elsherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonair H.","family":"Labib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Elalfy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa","family":"Elaasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"von Mackensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11"},{"key":"e_1_2_7_3_2","first-page":"1319","volume-title":"Wintrobe's Clinical Hematology (Volume 42)","author":"Borgna\u2010Pignatti C","year":"2004"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-73"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05545.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1229.004k32_1229_1236"},{"key":"e_1_2_7_7_2","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna\u2010Pignatti C","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000203853"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-2-3"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ec0f13"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2948"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087888"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09740-4"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.019"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05586.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243801"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01183.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq224"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.13.2391"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.03.018"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01228.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217455"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.014696"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.031468"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.019042"},{"key":"e_1_2_7_26_2","first-page":"579","article-title":"Issues in the management of satisfaction with treatment","volume":"3","author":"Weaver M","year":"1997","journal-title":"A J Manag Care"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1998.tb01940.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000313447"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0037-7856(76)90136-0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00390.x"},{"key":"e_1_2_7_31_2","article-title":"A questionnaire on treatment satisfaction and disease specific knowledge among patients with acute coronary syndrome. 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