{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:07:46Z","timestamp":1760249266528},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,11]],"date-time":"2011-12-11T00:00:00Z","timestamp":1323561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The time course of mild cardiotoxicity induced by anthracycline remains unknown. The aim of this study was to evaluate the long\u2010term evolution of decreased myocardial reserve in children previously treated with a cumulative dose of anthracycline up to 100\u2009mg\/m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Twenty\u2010seven asymptomatic cancer survival patients (25 with lymphoblastic leukemia), in continuous remission and off treatment for &gt;12 months with no alterations in conventional echocardiograms were evaluated by exercise echocardiography at 37\u2009\u00b1\u200915.4 months (T1) and 101\u2009\u00b1\u200924 months (T2) after finishing treatment (ADRIA group). This group was compared with 25 healthy individuals (control group) similar to the ADRIA group with respect to age and body surface area (BSA). All individuals underwent treadmill exercise testing according to Bruce protocol. Echocardiograms were performed before and immediately after exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups were similar regarding cardiac structure and left ventricular (LV) systolic function at rest at T1 and T2. The growth of LV posterior wall thickness related to BSA was lower in the ADRIA group at T2. Post exercise, smaller LV ejection indexes and attenuated changes in the afterload in ADRIA group were observed at T1 and T2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decreased systolic reserve induced by a low dose of anthracycline in asymptomatic children and adolescents remains unaffected over a 5\u2010year period, suggesting that positive outcomes in chronic cardiotoxicity would be expected in patients with mild impairment after anthracycline treatment. Pediatr Blood Cancer 2012;59:548\u2013552. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24000","type":"journal-article","created":{"date-parts":[[2011,12,11]],"date-time":"2011-12-11T17:17:26Z","timestamp":1323623846000},"page":"548-552","source":"Crossref","is-referenced-by-count":8,"title":["Ventricular systolic reserve in asymptomatic children previously treated with low doses of anthracyclines: A longitudinal, prospective exercise echocardiography study"],"prefix":"10.1002","volume":"59","author":[{"given":"Fabio V.","family":"Guimaraes\u2010Filho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doralice M.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao C. 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