{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:15:43Z","timestamp":1790864143186,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, \u03b1\u2010fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta\u2010like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver\u2010stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743\u2013745. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24024","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T21:55:37Z","timestamp":1324072537000},"page":"743-745","source":"Crossref","is-referenced-by-count":15,"title":["DLK1, a serum marker for hepatoblastoma in young infants"],"prefix":"10.1002","volume":"59","author":[{"given":"Farah A.","family":"Falix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter H.","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan K.","family":"Hiralall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Seppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11585"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0011"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(03)00092-7"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.4857"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.06.003"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810613"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00354.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971219)74:6<593::AID-IJC6>3.0.CO;2-P"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.022"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066170"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2007.07.002"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019809167228"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198101000-00012"},{"key":"e_1_2_7_15_2","first-page":"119","article-title":"The role of the epidermal growth factor\u2010like protein dlk in cell differentiation","volume":"15","author":"Laborda J","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2000.066001049.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00388"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20705"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.002"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0571-8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21328"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:13:21Z","timestamp":1696896801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/pbc.24024"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24024","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,16]]}}}