{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:49:27Z","timestamp":1774579767412,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known on strategies to prevent or to treat relapses occurring after haploidentical stem cell transplantation (haplo\u2010HSCT) performed for the high\u2010risk neuroblastoma (NB). We describe a 6\u2010year\u2010old male with refractory NB who relapsed 22 months after haplo\u2010HSCT. A complete remission was obtained with a combination of immuno\u2010chemotherapy based on donor NK cells transplants, IL2 infusions and temozolomide\/topotecan. This case is an incentive to explore both the immediate therapeutic effect of haplo\u2010graft provided via haplo\u2010NK cells and the immunogenic platform that haplo\u2010HSCT offers for future treatment. Our post\u2010relapse strategy shows that chemo\u2010 and bio\u2010treatment should be viewed as complementary therapeutic options. Pediatr Blood Cancer 2012;59:739\u2013742. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24030","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T21:56:27Z","timestamp":1324072587000},"page":"739-742","source":"Crossref","is-referenced-by-count":32,"title":["NK Cell immunotherapy for high\u2010risk neuroblastoma relapse after haploidentical HSCT"],"prefix":"10.1002","volume":"59","author":[{"given":"Justyna","family":"Kanold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Paillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Tchirkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Halle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Isfan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Merlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelien","family":"Marabelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Rochette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Dem\u00e9ocq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8925"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.69"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/152581603322286060"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2406"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-942256"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.11"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.141"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704070"},{"key":"e_1_2_5_10_2","first-page":"1","article-title":"KIR\u2010HLA receptor\u2013ligand mismatch associated with a graft versus tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumor","volume":"12","author":"Perez\u2010Martinez A","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.05.007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23035"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0505-6"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25035"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:13:05Z","timestamp":1696896785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/pbc.24030"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24030","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,16]]}}}