{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:52:33Z","timestamp":1778028753248,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term survivors of childhood acute lymphoblastic leukemia (ALL) have increased risk of cardiovascular disease (CVD). The prevalence of insulin resistance and other cardiometabolic risk factors is increased in ALL survivors, and insufficient physical activity (PA) and low cardiopulmonary fitness are common. The purpose of this study was to evaluate the effects of a simple, inexpensive home\u2010based exercise program on cardiometabolic risk factors and fitness in long\u2010term ALL survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Seventeen 16\u2010 to 30\u2010year\u2010old survivors of childhood ALL (age at diagnosis \u226416 years) were recruited to a 16\u2010week home\u2010based exercise program. Peak oxygen uptake (VO<jats:sub>2 peak<\/jats:sub>), muscle strength, and metabolic risk factors were studied before and after the exercise program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting plasma insulin (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), HOMA\u2010IR (homeostasis model assessment, insulin resistance) (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), waist circumference (<jats:italic>P<\/jats:italic>\u2009=\u20090.003), waist\u2010to\u2010hip ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), fat percent (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), and supine diastolic blood pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) decreased during the program, while weight and body mass index remained unchanged. VO<jats:sub>2 peak<\/jats:sub> and maximal work load (W\/kg) improved by 5% (<jats:italic>P<\/jats:italic>\u2009=\u20090.01 and <jats:italic>P<\/jats:italic>\u2009=\u20090.02, respectively) during the exercise program. The results of the Sit\u2010Up test, Back extensor test, and Full Squatting test improved as well (<jats:italic>P<\/jats:italic>\u2009=\u20090.01, <jats:italic>P<\/jats:italic>\u2009=\u20090.002, and <jats:italic>P<\/jats:italic>\u2009=\u20090.0004, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A simple home\u2010based exercise program was effective in improving cardiometabolic risk factor status and fitness in young adult survivors of childhood ALL. Simple exercise programs should be recommended to this population with increased risk of CVD to improve metabolic risk factor status and fitness. Pediatr Blood Cancer 2012; 59: 155\u2013160. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24049","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T19:09:42Z","timestamp":1324321782000},"page":"155-160","source":"Crossref","is-referenced-by-count":72,"title":["Effects of a home\u2010based exercise program on metabolic risk factors and fitness in long\u2010term survivors of childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"59","author":[{"given":"Liisa S.","family":"J\u00e4rvel\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kemppainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri","family":"Niinikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarna C.","family":"Hannukainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi M.","family":"L\u00e4hteenm\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kapanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Arola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli J.","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"HornerMJ RiesLAG KrapchoM et al.SEER Cancer Statistics Review 1975\u20132006 National Cancer Institute. 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