{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:41:24Z","timestamp":1772923284374,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular\u2010related toxicities have been reported among survivors of Hodgkin lymphoma (HL), but their genesis is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Fasting blood samples from 25 previously irradiated HL survivors were analyzed for biomarkers that can reveal underlying inflammation and\/or endothelial cell activation: high\u2010sensitivity C\u2010reactive protein (hsCRP), triglycerides, total cholesterol, high\u2010density lipoprotein (HDL), apolipoprotein \u00df, lipoprotein (a), fibrinogen, circulating endothelial cells (CECs), and vascular cell adhesion molecule\u20101 (VCAM\u20101) expression. Values were compared to subjects in the Coronary Artery Risk Development in Young Adults (CARDIA) study. CECs and VCAM\u20101 were compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survivors (76% male), median age 17.6 years (5\u201333) at diagnosis, 33.0 years (19\u201355) at follow\u2010up, included stages IA (n\u2009=\u20096), IIA (n\u2009=\u200910), IIB (n\u2009=\u20092), IIIA (n\u2009=\u20094), and IVA (n\u2009=\u20093) patients. Twenty\u2010four received at least chest radiation therapy (RT) (median dose 3,150 cGy; range: 175\u20104,650 cGy), one received neck only; 14 (56%) had a history of anthracycline exposure (median dose: 124\u2009mg\/m<jats:sup>2<\/jats:sup> range: 63\u2013200\u2009mg\/m2). Compared to CARDIA subjects, mean hsCRP (3.0\u2009mg\/L\u2009\u00b1\u20092.0 vs. 1.6\u2009\u00b1\u20091.9), total cholesterol (194.1\u2009mg\/dl\u2009\u00b1\u200933.2 vs. 179.4\u2009\u00b1\u200932.9), lipoprotein (a) (34.2\u2009mg\/dl\u2009\u00b1\u200917.5 vs. 13.8\u2009\u00b1\u200917.5), and fibrinogen (342.0\u2009mg\/dl\u2009\u00b1\u200949.1 vs. 252.6\u2009\u00b1\u200948.4) were significantly elevated. CECs (2.3 cells\/ml\u2009\u00b1\u20091.5 vs. 0.34\u2009\u00b1\u20091.4) were significantly elevated compared to controls. No difference in VCAM\u20101 expression (51.1%\u2009\u00b1\u200936.8 vs. 42.3\u2009\u00b1\u200935.6) was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HL survivors exposed to RT have evidence of vascular inflammation, dyslipidemia, and injury suggestive of early atherogenesis. Pediatr Blood Cancer 2012;59:285\u2013289. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24082","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T09:58:43Z","timestamp":1333015123000},"page":"285-289","source":"Crossref","is-referenced-by-count":19,"title":["Pilot study of vascular health in survivors of Hodgkin lymphoma"],"prefix":"10.1002","volume":"59","author":[{"given":"Daniel A.","family":"Mulrooney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Solovey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Hebbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Neaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung K.K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4606"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.8.618"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11095"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3227"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn310"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf167"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.121"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2831"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90574-X"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.6.1387"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90345-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1208"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510160067031"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372203"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034405"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk029"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.107"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00184-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22111"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1813"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.4.491"},{"key":"e_1_2_5_26_2","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1086\/652749","article-title":"Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection","volume":"201","author":"Neuhaus J","journal-title":"J Infect Dis"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.20.2007"},{"key":"e_1_2_5_28_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jama.1996.03540070040028","article-title":"Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. 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