{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:25:42Z","timestamp":1770747942134,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T00:00:00Z","timestamp":1335312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the epidemiologic and microbiological aspects of long\u2010term central vein catheter (CVC)\u2010associated bloodstream infections (CABSI) in children &lt;18 years old treated at the hemato\u2010oncology unit during 1998\u20132008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The two long\u2010term access devices used were Hickman and Port\u2010A\u2010Cath catheters. Information retrieved included demographic data, baseline pathologies, methods of insertion, anatomical insertion sites, duration of use, microbiological, and antibiotic susceptibility data and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 178 CABSI episodes; average number of episodes\/1,000 catheter days was 4.7. More CABSI episodes were recorded among patients with Hickman catheter than in patients with Port\u2010A\u2010Cath catheter (5.05 vs. 3.57\/1,000 catheter days, <jats:italic>P<\/jats:italic>\u2009=\u20090.059). The CVC was removed due to BSI in 52\/178 (29.2%) episodes. Overall, 243 pathogens were isolated (144 Gram\u2010negative, 92 Gram\u2010positive, and 7 <jats:italic>Candida<\/jats:italic> spp). More <jats:italic>Enterobacteriaceae<\/jats:italic> spp. were isolated in CABSI in patients with Hickman catheters than in patients with Port\u2010A\u2010Cath catheters (35\/103, 34%, vs. 10\/65, 15%, <jats:italic>P<\/jats:italic>\u2009=\u20090.008); more coagulase\u2010negative staphylococci were isolated in patients with Port\u2010A\u2010Cath catheters than in patients with Hickman catheters (25\/65, 38.5%, vs. 23\/103, 22.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). No differences in pathogen distribution were found between CABSI recorded for jugular versus subclavian veins, open versus close inserted\u2010CVC or for CVC requiring removal versus those treated conservatively. No fatalities directly related to CABSI were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CABSI rates were higher in patients with Hickman catheters compared with those with Port\u2010A\u2010Cath catheters; Gram\u2010negative organisms were the dominant etiologic agents of CABSI; CABSI in patients with Hickman catheters had different etiologies compared with patients with Port\u2010A\u2010Cath catheters. Pediatr Blood Cancer 2012;59:410\u2013414. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24135","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T14:58:48Z","timestamp":1335365928000},"page":"410-414","source":"Crossref","is-referenced-by-count":27,"title":["Central venous catheter\u2010associated bloodstream infections"],"prefix":"10.1002","volume":"59","author":[{"given":"Nitza","family":"Newman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Issa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kapelushnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahavi","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Leibovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir523"},{"key":"e_1_2_5_4_2","first-page":"438","article-title":"Guideline for prevention of intravascular\u2010device\u2010related infections","volume":"17","author":"Pearson ML","year":"1996","journal-title":"Infect Control Hosp Epidemiol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/501609"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000151393"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/598620"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/340402"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/502455"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01416.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.07.017"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0796-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi111"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(08)60022-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0968-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/501809"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199906000-00018"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000128779.34716.ee"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0687-1"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.01.020"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0266-7"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000284589.63641.B8"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T13:08:52Z","timestamp":1696770532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,25]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/pbc.24135"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24135","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,25]]}}}