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We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized\u2010controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega\u20103 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions. Pediatr Blood Cancer 2012;59:211\u2013215. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24163","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T14:53:27Z","timestamp":1334069607000},"page":"211-215","source":"Crossref","is-referenced-by-count":25,"title":["Micronutrients and sickle cell disease, effects on growth, infection and vaso\u2010occlusive crisis: A systematic review"],"prefix":"10.1002","volume":"59","author":[{"given":"Louise H.","family":"Dekker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Fijnvandraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Brabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Boele","family":"van Hensbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"2006 WHO Geneva Switzerland World Health Organization (WHO) Sickle\u2010cell anaemia"},{"key":"e_1_2_6_3_2","first-page":"704","article-title":"Inherited haemoglobin disorders: An increasing global health problem","volume":"79","author":"Weatherall DJ","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318045bdca"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.028167"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.051"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195088243.001.0001","volume-title":"Vitamin a deficiency: Health, survival and vision","author":"Sommer A","year":"1996"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1179\/146532808X335624"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04639.x"},{"key":"e_1_2_6_10_2","volume-title":"Sickle cell disease in childhood, standards and guidelines for clinical care","author":"NHS Antenal and Newborn Screening Programmes","year":"2007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00292.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830290203"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31248-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/43.4.220"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90053-2"},{"key":"e_1_2_6_16_2","unstructured":"National Institute of Health (NIH).Dietary supplement fact sheet: Folate. 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