{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:25Z","timestamp":1790511025933,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persistence of humoral immunity was evaluated in 82 hematopoietic stem cell transplant recipients up to 12.5 years after post\u2010transplant immunization against tetanus and diphtheria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>New immunization, initiated at least 12 months after transplantation, consisted of an average three\u2010dose schedule of vaccine administration on day 1, month 3, and month 12. Serological data were collected at pre\u2010transplant, post\u2010transplant, vaccination, and post\u2010vaccination time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first vaccination dose elicited a seroprotective response in most recipients, but the complete vaccine series (usually three\u2010dose schedule) reinforced the specific immunity in most vaccinated cases, that is, 100% and 95.8% seroprotection against tetanus and diphtheria, respectively. Geometric mean concentration post\u2010vaccination tetanus and diphtheria antibody levels persisted at 1.9\u2009IU (95% CI: 1.23\u20132.94\u2009IU\/ml) and 0.20\u2009IU (95% CI: 0.11\u20130.38\u2009IU\/ml) for 7 years, respectively. However, diphtheria antibodies were lost not significantly but much faster and more often than tetanus antibodies, though the seroprotection rates against tetanus and diphtheria remained favorable, that is, 100% (95% CI: 85.2\u2013100%) and 87% (95% CI: 59.5\u201398.3%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Full post\u2010transplant revaccination resulted in long\u2010term persistence of humoral immunity against tetanus and diphtheria in SCT recipients, for an average of 8.6 and 9.0 years, respectively. Pediatr Blood Cancer 2012; 59: 908\u2013913. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24186","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T18:09:13Z","timestamp":1334772553000},"page":"908-913","source":"Crossref","is-referenced-by-count":8,"title":["Persistence of humoral immunity to tetanus and diphtheria in hematopoietic stem cell transplant recipients after post\u2010transplant immunization"],"prefix":"10.1002","volume":"59","author":[{"given":"Jitka","family":"\u0160kovr\u00e1nkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Petr\u00e1\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1182\/blood.V84.12.4374.bloodjournal84124374","article-title":"Clonal dysregulation of the antibody response to tetanus\u2010toxoid after bone marrow transplantation","volume":"84","author":"Gerritsen EJ","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819d31bc"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9181-0"},{"key":"e_1_2_6_5_2","first-page":"1","article-title":"Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients","volume":"49","author":"Centers for Disease Control and Prevention; Infectious Disease Society of America; American Society of Blood and Marrow Transplantation","year":"2000","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.2.496"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/511641"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700768"},{"key":"e_1_2_6_9_2","first-page":"225","article-title":"Immune status and immune response to diphtheria\u2013tetanus and polio vaccines in allogeneic bone marrow\u2010transplanted thalassemic patients","volume":"14","author":"Li Volti S","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704678"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08913.x"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:28:34Z","timestamp":1696847314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/pbc.24186"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24186","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}