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A small number of case\u2013control studies investigating risk factors for sporadic hepatoblastoma have been conducted to date. Although most of these studies feature fewer than 200 cases, several clues have emerged. Most notably there is a roughly 20\u2010fold increased risk of hepatoblastoma among children with very low birth weight (&lt;1,500\u2009g) and a doubling of risk among those with moderately low birth weight (1,500\u20132,500\u2009g). A modicum of evidence points to a possible role of parental tobacco use prior to or during pregnancy in the causation of hepatoblastoma as well. Pediatr Blood Cancer 2012; 59: 776\u2013779. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24215","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T14:43:53Z","timestamp":1339512233000},"page":"776-779","source":"Crossref","is-referenced-by-count":290,"title":["The epidemiology of hepatoblastoma"],"prefix":"10.1002","volume":"59","author":[{"given":"Logan G.","family":"Spector","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Birch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"SEER cancer statistics review, 1975\u20132008","author":"Howlader N","year":"2011"},{"key":"e_1_2_5_3_2","volume-title":"Cancer incidence and survival among children and adolescents: United States: SEER Program 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