{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:30:16Z","timestamp":1790389816415,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The principal aim of this study was to identify the lowest nodule diameter and the SUV<jats:sub>max<\/jats:sub> capable of characterizing lung nodules in pediatric patients with bone sarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Eighteen consecutive bone sarcoma patients (M\/F\u2009=\u200911:7; mean age 14 years) with suspicious lung lesions at CT were enrolled. Overall, 63 lung nodules with a mean diameter of 3.35\u2009mm (range 1.2\u201339.8\u2009mm) were investigated. <jats:sup>18<\/jats:sup>F\u2010FDG PET was performed according to standard procedure using a hybrid PET\/CT system and results were compared with histology and\/or clinical\/radiological follow\u2010up. For each lesion, we evaluated SUV<jats:sub>max<\/jats:sub>, SUV<jats:sub>ratio<\/jats:sub> to the mediastinal blood pool and maximum nodule diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 63 nodules, 32 proved to be benign and 31 malignant. On a visual basis, <jats:sup>18<\/jats:sup>F\u2010FDG PET had an accuracy of 88.9%, a sensitivity of 90.3%, a specificity of 87.5%, a PPV of 87.5%, and a NPV of 90.3%. ROC curve analysis of SUV<jats:sub>max<\/jats:sub> for all nodules showed a value around 1 (&gt;1.09) to be capable of differentiating metastases from benign lesions: sensitivity and specificity were 90.3% and 93.8%, respectively (accuracy 92.1%). Similar analysis revealed a cut\u2010off value around 1 (&gt;0.83) for SUV<jats:sub>ratio<\/jats:sub> (sensitivity and specificity were 90.3% and 90.6%, respectively) and a cut\u2010off value of ca. 6\u2009mm (&gt;5.8\u2009mm) for nodule diameter (sensitivity and specificity of 90.3% and 81.3%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT is an accurate modality for the metabolic characterization of lung nodules in the pediatric population with bone sarcoma, and a SUV<jats:sub>max<\/jats:sub> (or SUV<jats:sub>ratio<\/jats:sub>) &gt;1 is capable of discriminating malignant from benign lesions. Pediatr Blood Cancer 2012; 59: 1206\u20131210. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24242","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T15:36:43Z","timestamp":1340897803000},"page":"1206-1210","source":"Crossref","is-referenced-by-count":56,"title":["The role of <sup>18<\/sup>F\u2010FDG PET\/CT in the metabolic characterization of lung nodules in pediatric patients with bone sarcoma"],"prefix":"10.1002","volume":"59","author":[{"given":"Angela","family":"Cistaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egesta","family":"Lopci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gastaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Fania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Brach del Prever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Fagioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-009-0237-5"},{"key":"e_1_2_7_3_2","first-page":"426","article-title":"Accuracy of PET for diagnosis of solid pulmonary lesions with 18F\u2010FDG uptake below the standardized uptake value of 2.5","volume":"47","author":"Hashimoto Y","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0345-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318146233b"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0018-x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2392050631"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011111322376"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21369"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.4.561"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.07.072"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3108"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0284-9_1"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.11.010"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.2473"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21596"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187656"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013103511633"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000359"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-001-0662-8"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:52:21Z","timestamp":1700589141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,12,15]]}},"alternative-id":["10.1002\/pbc.24242"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24242","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}