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This treatment has substantially lowered the number of children exposed to human plasma derived products, with a good safety profile, and at very low cost. The response to DDAVP has been shown to be associated with age, baseline factor level, and genetic mutations. A DDAVP challenge test is recommended. DDAVP has also been used to prevent and treat bleeding episodes in children with platelet function defects and other disorders associated with bleeding tendency. Pediatr Blood Cancer 2012; 60: S41\u2013S43. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24335","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T12:53:22Z","timestamp":1351169602000},"source":"Crossref","is-referenced-by-count":12,"title":["The use of DDAVP in children with bleeding disorders"],"prefix":"10.1002","volume":"60","author":[{"given":"Tal","family":"Ben\u2010Ami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Revel\u2010Vilk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00059.x"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460308"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91197-7"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996055"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000161213.54024.7f"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00190.x"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614626"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01610.x"},{"key":"e_1_2_2_10_2","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1182\/blood.V74.6.1997.1997","article-title":"Consistency of responses to repeated DDAVP infusions in patients with von Willebrand's disease and hemophilia A","volume":"74","author":"Rodeghiero F","year":"1989","journal-title":"Blood"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200311000-00010"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.1915"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02067.x"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-04-0220"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02572.x"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03507.x"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80384-1"},{"key":"e_1_2_2_18_2","first-page":"117","article-title":"Evidence\u2010based recommendations on the treatment of von Willebrand disease in Italy","volume":"7","author":"Mannucci PM","year":"2009","journal-title":"Blood Transfus"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109231"},{"key":"e_1_2_2_20_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-0037-1617014","article-title":"Response to DDAVP in children with von Willebrand disease type 2","volume":"29","author":"Schneppenheim R","year":"2009","journal-title":"Hamostaseologie"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01672.x"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22988"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01607.x"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0792-9"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02504.x"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02011.x"},{"key":"e_1_2_2_27_2","first-page":"146","article-title":"Circumcision in a combined factor V and factor VIII deficiency using desmopressin (DDAVP)","volume":"44","author":"Devecioglu O","year":"2002","journal-title":"Turk J Pediatr"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07446.x"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000224855.88366.4c"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199221000-00005"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31818db18b"},{"key":"e_1_2_2_32_2","first-page":"CD008085","article-title":"Pharmacological interventions to decrease blood loss and blood transfusion requirements for liver resection","author":"Gurusamy KS","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029610366440"},{"key":"e_1_2_2_34_2","first-page":"207","article-title":"Response of patients with hemophilia A and von Willebrand disease to desmopressin (DDAVP)","volume":"82","author":"Santiago\u2010Borrero PJ","year":"1990","journal-title":"Bol Asoc Med P R"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330108"},{"key":"e_1_2_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20210"}],"container-title":["Pediatric Blood &amp; 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