{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:04:27Z","timestamp":1773248667117,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary immune thrombocytopenia (ITP) in childhood, typically presents as an acute self\u2010limiting illness. However, secondary ITP is often a chronic disorder due to an underlying disease. Combined cytopenias in childhood, that is, secondary ITP occurring with auto\u2010immune hemolytic anemia and\/or auto\u2010immune neutropenia, are often associated with disorders characterized by immune dysregulation. Such disorders include systemic lupus erythematosus, auto\u2010immune lymphoproliferative syndrome, and common variable immune deficiency. Evans syndrome describes the combination of ITP, autoimmune hemolytic anemia, and\/or autoimmune neutropenia. However, it is now clear that some patients with Evans syndrome have an underlying immunodeficiency. This report focuses on combined auto\u2010immune cytopenias and highlights the challenges in their diagnosis and management. Pediatr Blood Cancer 2012; 60: S12\u2013S14. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24343","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T12:51:28Z","timestamp":1351169488000},"source":"Crossref","is-referenced-by-count":10,"title":["Auto\u2010immune lymphoproliferative disorder and other secondary immune thrombocytopenias in childhood"],"prefix":"10.1002","volume":"60","author":[{"given":"Victoria","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"562","article-title":"Idiopathic thrombocytopenic purpura in childhood","volume":"97","author":"Choi SI","year":"1967","journal-title":"Can Med Assoc J"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010501"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2008.12.005"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374960100011101"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00052-1"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.1.3.3"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1951.03810010058005"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3542"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-239525"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5225"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401190"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70272-8"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07991.x"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2583"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:20:1:109"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701356473"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-280347"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-254417"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7510905"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05496.x"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07595.x"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24343","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T19:22:25Z","timestamp":1694892145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":23,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/pbc.24343"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24343","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}