{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:32:26Z","timestamp":1697689946252},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperhomocysteinemia may be associated with vascular complications in adults. Whereas pediatric thrombosis risk peaks in neonates, data on homocysteine (Hcy) levels assessed in term and preterm infants during the perinatal period are scarce. In the present study, we aimed to establish Hcy reference values for preterm infants and study their potential associations with the early post\u2010natal health status. Plasma Hcy and hematocrit levels and MTHFR polymorphisms (C677T and A1298C substitution) were studied in a large cohort of preterm infants in a tertiary referral medical center during an 18\u2010month period. Data were collected on maternal history and delivery as well as on post\u2010natal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 167 infants whose mean gestational age was 30.98\u2009\u00b1\u20092.34 weeks (range: 26\u201336 weeks), mean birth weight 1327.6\u2009\u00b1\u2009327\u2009g, and mean Hcy level 7.99\u2009\u00b1\u20093.27 (range: 2.2\u201321.2)\u2009\u00b5mol\/L. Maternal intake of folic acid was inversely associated with the babies' Hcy levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Increased Hcy levels positively correlated with birth weight, gestational age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005), total number of pregnancies (<jats:italic>P<\/jats:italic>\u2009=\u20090.012), and presence of MTHFR polymorphism. Higher Hcy levels were associated with feeding (<jats:italic>P<\/jats:italic>\u2009=\u20090.008), especially total parenteral nutrition (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001). There was no correlation between Hcy levels and any vascular post\u2010natal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During their post\u2010natal hospitalization, preterm infants may have relatively high, that is, within the adult normal range, Hcy levels which are influenced by genetic and environmental factors. Despite the fact that no correlation was found between Hcy levels and post\u2010natal complications, these associations should be further studied. Pediatr Blood Cancer 2013; 60: 659\u2013662. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24352","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T13:34:03Z","timestamp":1349012043000},"page":"659-662","source":"Crossref","is-referenced-by-count":2,"title":["The impact of genetic and environmental factors on homocysteine levels in preterm neonates"],"prefix":"10.1002","volume":"60","author":[{"given":"Ayala","family":"Maayan\u2010Metzger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Lubetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Kuint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurit","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal J.","family":"Simchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Kuperman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzipora","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010Ami","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.214"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341203"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0093"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0290"},{"key":"e_1_2_5_6_2","first-page":"280","article-title":"Vascular access\u2010related thrombotic complications: Research hypotheses and therapeutic strategies","volume":"19","author":"Bruno S","year":"2006","journal-title":"J Nephrol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1160\/TH05-11-0737","article-title":"Antiphospholipid antibodies and hyperhomocysteinaemia in patients with vascular occlusive disease","volume":"96","author":"Casais P","year":"2006","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/7A33-8EQ4-QT98-3TPX"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1731S"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385855-9.00005-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1726S"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014332"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2070"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.126598"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0290-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.83.3.708"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000014143"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.036194"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2010.235"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1160\/TH03-02-0089","article-title":"Thrombophilia does not increase risk for neonatal complications in preterm infants","volume":"90","author":"Kenet G","year":"2003","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-7-38"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80438-3"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103745"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60872-6"}],"container-title":["Pediatric Blood &amp; 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