{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:15:39Z","timestamp":1768569339807,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although hematopoietic stem cell transplantation (HSCT) is the treatment of choice for childhood myelodysplastic syndrome (MDS), there is no consensus regarding patient or disease characteristics that predict outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We reviewed 37 consecutive pediatric MDS patients who received myeloablative HSCT between 1990 and 2010 at a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty had primary MDS and 17 had secondary MDS. Diagnostic cytogenetics included monosomy 7 (n\u2009=\u200921), trisomy 8 (n\u2009=\u20097) or normal\/other (n\u2009=\u20098). According to the modified WHO MDS classification, thirty had refractory cytopenia and seven had refractory anemia with excess blasts. IPSS scores were: low risk (n\u2009=\u20091), intermediate\u20101 (n\u2009=\u200915), and intermediate\u20102 (n\u2009=\u200921). OS and DFS at 10 years in the entire cohort was 53% and 45%. Relapse at 10 years was 26% and 1 year TRM was 25%. In multivariate analysis, factors associated with improved 3 years DFS were not receiving pre\u2010HSCT chemotherapy (RR\u2009=\u20090.30, 95% CI 0.10\u20130.88; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) and a shorter interval (&lt;140 days) from time of diagnosis to transplant (RR\u2009=\u20090.27, 95% CI 0.09\u20130.80; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Three years DFS in patients who did not receive pre\u2010HSCT chemotherapy and those who had a shorter interval to transplant (n\u2009=\u200916) was 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that children with MDS should be referred for allogeneic HSCT soon after diagnosis and that pre\u2010HSCT chemotherapy does not appear to improve outcomes. Pediatr Blood Cancer 2013; 60: 705\u2013710. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24390","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T18:06:53Z","timestamp":1352916413000},"page":"705-710","source":"Crossref","is-referenced-by-count":32,"title":["Early hematopoietic stem cell transplant is associated with favorable outcomes in children with MDS"],"prefix":"10.1002","volume":"60","author":[{"given":"Angela R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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