{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:36:39Z","timestamp":1785450999719,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the publication of the Prophlyactic Penicillin Study II in 1995, the management of penicillin prophylaxis for children with sickle cell disease (SCD) after 5 years of age has been controversial. In this study, we sought to describe current practice patterns of pediatric hematologists related to cessation of penicillin prophylaxis for children with SCD after 5 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We performed a cross\u2010sectional, electronic survey of pediatric hematologists with expertise in SCD to examine practices regarding penicillin prophylaxis in children with SCD after 5 years of age. We also investigated factors potentially associated with continuation of penicillin prophylaxis using the Jonckheere\u2013Terpstra test and Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 106 physicians surveyed from 76 centers, 84% completed the survey. Among respondents, 76% routinely recommended cessation of penicillin prophylaxis after 5 years of age. The practice of routinely continuing penicillin after 5 years of age was associated with decreased concern about antibiotic resistance in <jats:italic>Streptococcus pneumoniae<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), with the usage of prophylactic penicillin in mild SCD genotypes (sickle hemoglobin\u2010C disease and sickle \u03b2<jats:sup>+<\/jats:sup> thalassemia, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;0.001), and with increasing use of other preventive evaluations (e.g., MRI for silent stroke) in childhood (<jats:italic>P<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most pediatric hematologists with an SCD expertise recommend cessation of prophylactic penicillin after 5 years of age. Pediatr Blood Cancer 2013; 60: 935\u2013939. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24395","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T01:50:30Z","timestamp":1354153830000},"page":"935-939","source":"Crossref","is-referenced-by-count":15,"title":["Prophylactic penicillin after 5 years of age in patients with sickle cell disease: A survey of sickle cell disease experts"],"prefix":"10.1002","volume":"60","author":[{"given":"Timothy L.","family":"McCavit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197103000-00002"},{"key":"e_1_2_6_3_2","first-page":"784","article-title":"Bacterial meningitis and septicemia in sickle cell disease","volume":"131","author":"Overturf GD","year":"1977","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1542\/peds.72.1.93","article-title":"Bacterial infection and splenic reticuloendothelial function in children with hemoglobin SC disease","volume":"72","author":"Buchanan GR","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83171-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/peds.76.3.392","article-title":"Developmental pattern of splenic dysfunction in sickle cell disorders","volume":"76","author":"Pearson HA","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood.V85.8.2238.bloodjournal8582238","article-title":"Functional asplenia in hemoglobin SC disease","volume":"85","author":"Lane PA","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142501"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70154-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.022"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3686"},{"key":"e_1_2_6_13_2","first-page":"CD003427","article-title":"Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease","author":"Riddington C","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/516781"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0018"},{"key":"e_1_2_6_16_2","unstructured":"AdamkiewiczT.Personal discussion unpublished data from citation #14 2012."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1784"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.e7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70107-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199605000-00008"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00331-7"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.025"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182480fed"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880010903360367"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:37:41Z","timestamp":1697654261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/pbc.24395"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24395","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}