{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:47:33Z","timestamp":1780606053900,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The frontline treatment for chronic myeloid leukemia (CML) is tyrosine kinase inhibitor therapy. There is increasing evidence that imatinib results in growth failure in children; etiology is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The cross\u2010sectional study was conducted from January 2011 to June 2012 in a pediatric oncology unit. Patients with chronic\u2010phase CML, receiving imatinib for more than 6 months were enrolled. Growth hormone (GH): Insulin like growth factor\u20101 (IGF\u20101) axis was evaluated by GH stimulation test by insulin tolerance and clonidine stimulation test, among other hormonal assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients with a median age of 12.9 years (range 6.5\u201317) completed the study. The mean duration of imatinib therapy was 43.7\u2009\u00b1\u200932.8 months. The height\u2010for\u2010age <jats:italic>z<\/jats:italic>\u2010scores at the start of imatinib and at enrollment were \u22121.07\u2009\u00b1\u20090.88 and \u22121.8\u2009\u00b1\u20090.98, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Seven (39%) patients were GH deficient and lacked a sufficient response to either of the two stimulation tests. Majority, 16 (89%) patients had IGF\u20101 <jats:italic>z<\/jats:italic>\u2010scores less than the mean. IGFBP\u20103 levels were below the mean in all patients. Every patient had deficiency of either GH, or IGF\u20101, or both. Bone age was delayed in 7 (39%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that imatinib results in growth failure in children with CML by disturbing the GH:IGF\u20101 axis. GH stimulation test and serum IGF\u20101 levels should be performed in children on treatment with imatinib who have growth retardation. Future studies should evaluate the role of recombinant GH therapy for ameliorating the adverse effect on growth. Pediatr Blood Cancer 2013; 60: 1148\u20131153. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24397","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T15:00:07Z","timestamp":1358262007000},"page":"1148-1153","source":"Crossref","is-referenced-by-count":73,"title":["Growth failure in children with chronic myeloid leukemia receiving imatinib is due to disruption of GH\/IGF\u20101 axis"],"prefix":"10.1002","volume":"60","author":[{"given":"Karthik R.","family":"Narayanan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Walia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Marwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11895"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-380774"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22484"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.7114"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.046"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23389"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61023-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0251-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.150"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3324\/haematol.2009.008359","article-title":"Longitudinal growth retardation in a prepuberal girl with chronic myeloid leukemia on long\u2010term treatment with imatinib","volume":"94","author":"Schmid H","year":"2009","journal-title":"Haematologica"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24121"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22945"},{"key":"e_1_2_6_14_2","unstructured":"who.int [homepage on the internet]. 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