{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:28:18Z","timestamp":1769606898577,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["NIH U10 CA98543"],"award-info":[{"award-number":["NIH U10 CA98543"]}]},{"name":"Children's Oncology Group Chair's","award":["SDC U10 CA98413"],"award-info":[{"award-number":["SDC U10 CA98413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The discovery of effective re\u2010induction regimens for children with more than one relapse of acute lymphoblastic leukemia (ALL) remains elusive. The novel nucleoside analog clofarabine exhibits modest single agent efficacy in relapsed ALL, though optimal combinations of this agent with other active chemotherapy drugs have not yet been defined. Herein we report the response rates of relapsed ALL patients treated on Children's Oncology Group study AAML0523, a Phase I\/II study of the combination of clofarabine and cytarabine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>AAML0523 enrolled 21 children with ALL in second or third relapse, or those refractory to re\u2010induction therapy. The study consisted of two phases: a dose finding phase and an efficacy phase. The dose finding portion consisted of a single dose escalation\/de\u2010escalation of clofarabine for 5 days in combination with a fixed dose of cytarabine (1\u2009g\/m<jats:sup>2<\/jats:sup>\/day for 5 days). Eight patients received clofarabine at 40\u2009mg\/m<jats:sup>2<\/jats:sup>\/day and 13 patients at 52\u2009mg\/m<jats:sup>2<\/jats:sup>\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Toxicities observed at all doses of clofarabine were typical of intensive chemotherapy regimens for leukemia, with infection being the most common. We did not observe significant hepatotoxicity as reported in other clofarabine combination regimens. The recommended pediatric Phase II dose of clofarabine in combination with cytarabine for the efficacy portion of AAML0523 was 52\u2009mg\/m<jats:sup>2<\/jats:sup>. Of 21 patients with ALL, 3 (14%) achieved a complete response (CR). Based on the two\u2010stage design definition of first\u2010stage inactivity, the therapy was deemed ineffective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of clofarabine and cytarabine in relapsed\/refractory childhood ALL does not warrant further clinical investigation. Pediatr Blood Cancer 2013; 60: 1141\u20131147. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24398","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T14:04:40Z","timestamp":1358431480000},"page":"1141-1147","source":"Crossref","is-referenced-by-count":17,"title":["Phase I\/II trial of clofarabine and cytarabine in children with relapsed\/refractory acute lymphoblastic leukemia (AAML0523): A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"60","author":[{"given":"Todd M.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem I.","family":"Razzouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gerbing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd A.","family":"Alonzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Adlard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Raetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Gamis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Perentesis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Whitlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506153322407"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.11.4243"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.7405"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00080a029"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01484-3"},{"key":"e_1_2_6_7_2","first-page":"3580","article-title":"DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4\u2010hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine","volume":"7","author":"Yamauchi T","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0026-895X(24)12176-1","article-title":"Comparison of the mechanism of cytotoxicity of 2\u2010chloro\u20109\u2010(2\u2010deoxy\u20102\u2010fluoro\u2010beta\u2010D\u2010arabinofuranosyl)adenine, 2\u2010chloro\u20109\u2010(2\u2010deoxy\u20102\u2010fluoro\u2010beta\u2010D\u2010ribofuranosyl)adenine, and 2\u2010chloro\u20109\u2010(2\u2010deoxy\u20102,2\u2010difluoro\u2010beta\u2010D\u2010ribofuranosyl)adenine in CEM cells","volume":"55","author":"Parker WB","year":"1999","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2122"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.8554"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0906-y"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1933"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199701000-00010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199502000-00006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403097"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.2950"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.9743"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374710"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07882.x"}],"container-title":["Pediatric Blood &amp; 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