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These patients have no anemia, little evidence of hemolysis and generally have a benign clinical course compared to other types of sickle cell anemia. We describe a 19\u2010year\u2010old male with HbS\u2010HPFH who had no history of anemia or vaso\u2010occlusive crisis, who presented with a massive splenic infarct. We conclude that patients with HbS\u2010HPFH can occasionally present with severe complications and require a high level of clinical suspicion for complications when presenting to the hospital. Pediatr Blood Cancer 2013; 60: E49\u2013E51. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/pbc.24444","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T20:15:37Z","timestamp":1357071337000},"source":"Crossref","is-referenced-by-count":7,"title":["Massive splenic infarction in an adolescent with hemoglobin S\u2010HPFH"],"prefix":"10.1002","volume":"60","author":[{"given":"Donna","family":"Whyte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Forget","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.K.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010yuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Pashankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10460.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb07607.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb27774.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V21.3.261.261"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08916.x"},{"key":"e_1_2_4_7_2","first-page":"20","volume-title":"Sickle cell disease","author":"Konotey\u2010Ahulu FID","year":"1973"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1958.tb03844.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10049"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.06.020"},{"key":"e_1_2_4_11_2","first-page":"531","article-title":"Massive splenic infarction in doubly abnormal heterozygous sickling disorders: A new complication of acute splenic sequestration syndrome","volume":"155","author":"Berry RA","year":"1991","journal-title":"West J Med"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.129.5.927"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31815aed7d"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1954.02940360009003"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195409092511102"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830270111"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(89)80410-3"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22015"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24444","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:06:29Z","timestamp":1700640389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,31]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/pbc.24444"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24444","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,31]]}}}