{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:11Z","timestamp":1788871691864,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010733","name":"Danish Childhood Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High\u2010dose cytarabine has been associated with a high frequency of viridans group streptococcal (VGS) bacteraemia. VGS bacteraemia causes considerable morbidity and mortality. The Nordic Society of Paediatric Haematology and Oncology (NOPHO)\u2010AML protocols use higher cumulated doses of cytarabine and more chemotherapy series (n\u2009=\u20096) than other protocols with the potential increased risk of severe VGS infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Medical records of all Danish children enrolled on the NOPHO\u2010AML\u20102004 protocol between January 2004 and September 2011 (n\u2009=\u200945) were retrospectively reviewed and all febrile episodes were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following 236 courses of chemotherapy, 112 positive blood cultures were registered. VGS were found in 38% of all positive blood cultures. Infectious episodes with VGS resulted in more days of fever and intravenous antibiotic therapy compared with infections caused by other microorganisms. VGS were involved in 45% of all episodes categorized as sepsis (n\u2009=\u200951) and in 67% of life\u2010threatening bloodstream infections (n\u2009=\u20099). Penicillin resistance was found in 40% of the VGS strains. No significant difference was observed in the proportion of VGS isolated following courses with low\u2010dose cytarabine versus courses with high\u2010dose cytarabine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VGS were the most commonly isolated pathogens causing the most severe infections and the majority of life\u2010threatening infections. A substantial proportion of the strains were resistant to penicillin. The high rate of VGS seemed independent of high\u2010dose cytarabine but was more likely caused by the intensive chemotherapy treatment leading to severe mucositis and neutropenia. Pediatr Blood Cancer 2013; 60: 1154\u20131160. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.24448","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T15:16:08Z","timestamp":1357053368000},"page":"1154-1160","source":"Crossref","is-referenced-by-count":24,"title":["High frequency of streptococcal bacteraemia during childhood AML therapy irrespective of dose of cytarabine"],"prefix":"10.1002","volume":"60","author":[{"given":"Katrine Helle","family":"Johannsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette M\u00f8ller","family":"Handrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Lausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schr\u00f8der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403962"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-091942"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403188"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08389.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/427329"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/383048"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/598620"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31822817a6"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1845"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.118886"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2006.06.008"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.3.453"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019509029589"},{"key":"e_1_2_5_15_2","first-page":"565","article-title":"Cytosine arabinoside as a major risk factor for streptococcus viridans septicemia following bone marrow transplantation: A 5\u2010year prospective study","volume":"16","author":"Engelhard D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00272-7"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.6829"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-416701"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20706"},{"key":"e_1_2_5_20_2","first-page":"266","article-title":"Polymicrobial bacteremia in pediatric patients","volume":"138","author":"Frommell GT","year":"1984","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90009-4"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21250"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.6.1201"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-007-0014-2"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6988.1169"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92259-1"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23563"}],"container-title":["Pediatric Blood &amp; 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