{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:12:03Z","timestamp":1768677123010,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Children's Cancer Research Fund, Karen Wyckoff Rein in Sarcoma Fund, Vikings Children's Fund","award":["1K12RR023247"],"award-info":[{"award-number":["1K12RR023247"]}]},{"name":"Children's Cancer Research Fund, Karen Wyckoff Rein in Sarcoma Fund, Vikings Children's Fund","award":["5PO1HL055552-13"],"award-info":[{"award-number":["5PO1HL055552-13"]}]},{"name":"Children's Cancer Research Fund, Karen Wyckoff Rein in Sarcoma Fund, Vikings Children's Fund","award":["01DK072124-01A3"],"award-info":[{"award-number":["01DK072124-01A3"]}]},{"name":"Minnesota Medical Foundation, Minneapolis, MN. Cancer Center Support","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}]},{"name":"National Institutes of Health, Bethesda, MD"},{"name":"American Lebanese Syrian Associate Charities (ALSAC), Memphis, TN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular\u2010related toxicities have been reported among survivors of osteosarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fasting blood samples from 24 osteosarcoma survivors were analyzed for high\u2010sensitivity C\u2010reactive protein (hsCRP), triglycerides, total cholesterol, high\u2010density lipoprotein (HDL), apolipoprotein\u2010\u00df, lipoprotein (a), fibrinogen, circulating endothelial cells (CECs), and surface expression of vascular cell adhesion molecule\u20101 (VCAM\u20101). Values were compared to subjects in the natural history Coronary Artery Risk Development in Young Adults (CARDIA) cohort study except for CECs and VCAM\u20101 expression, which were compared to controls studied at the University of Minnesota Lillehei clinical trials unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Survivors (54.2% male), median age 18 years (9\u201332) at diagnosis, 36.5 years (20\u201356) at evaluation were treated with a variety of chemotherapeutic exposures, all but one were exposed to doxorubicin (median dose 450\u2009mg\/m<jats:sup>2<\/jats:sup>; range: 90\u2013645\u2009mg\/m<jats:sup>2<\/jats:sup>), 14 (58.3%) received cisplatin, and 3 (12.5%) were exposed to carboplatin. Two survivors (8.3%) received radiation therapy for disease relapse. Compared to CARDIA subjects, mean hsCRP (3.0\u2009mg\/L\u2009\u00b1\u20092.0 vs. 1.6\u2009\u00b1\u20092.3), triglycerides (151\u2009mg\/dl\u2009\u00b1\u200981.7 vs. 95.4\u2009\u00b1\u2009101.3), lipoprotein (a) (34.9\u2009mg\/dl\u2009\u00b1\u200917.7 vs. 13.8\u2009\u00b1\u200922.0), and fibrinogen (315.0\u2009mg\/dl\u2009\u00b1\u200949.3 vs. 252.4\u2009\u00b1\u200961.7) were significantly elevated. The number of CECs (0.47\u2009cells\/ml\u2009\u00b1\u20092.5 vs. 0.92\u2009\u00b1\u20092.5) did not differ while surface expression of VCAM\u20101 (86.4%\u2009\u00b1\u200934.0 vs. 42.1\u2009\u00b1\u200933.8) was significantly elevated compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among survivors of osteosarcoma, assessed a median of 14 years from diagnosis, there is evidence of vascular inflammation, dyslipidemia, and early atherogenesis. Pediatr Blood Cancer 2013;60:1703\u20131708. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24610","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T11:38:49Z","timestamp":1369913929000},"page":"1703-1708","source":"Crossref","is-referenced-by-count":14,"title":["Pilot study of vascular health in survivors of osteosarcoma"],"prefix":"10.1002","volume":"60","author":[{"given":"Daniel A.","family":"Mulrooney","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Departments of Medicine and Pediatrics University of Tennessee Health Sciences Center, College of Medicine Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten 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Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Neaton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Masonic Cancer Center and School of Public Health, University of Minnesota Minnesota Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis R.","family":"Clohisy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Masonic Cancer Center and School of Public Health, University of Minnesota Minnesota Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Masonic Cancer Center and School of Public Health, University of Minnesota Minnesota Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Masonic Cancer Center and School 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