{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:49:17Z","timestamp":1771854557799,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Children's Hospital of Eastern Ontario Research Institute","award":["RS2012-12"],"award-info":[{"award-number":["RS2012-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion of packed red blood cells is common in pediatric cancer patients who receive chemotherapy. This study was done to identify characteristics of pediatric cancer patients at risk of hyperferritinemia secondary to frequent transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>In this retrospective chart review, all pediatric cancer patients who completed chemotherapy from January 2007 to January 2012 and had an assessment of serum ferritin 6 months after the end of treatment were included. Variables included: age, sex, type of cancer diagnosis, weight and body surface area (BSA) at the time of diagnosis, number of transfusions, total transfused volume (TTV), total transfused volume per body weight (TVPBW), and weight and BSA change from the time of diagnosis to the time of ferritin check.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 109 eligible patients, 85 (78%) received transfusions. Sixteen patients (14.7%) had ferritin levels\u2009&gt;\u2009200\u2009\u00b5g\/L and four (3.7%) had ferritin levels\u2009&gt;\u20091,000\u2009\u00b5g\/L. Although age, weight and BSA at cancer diagnosis, number of transfusions and TVPBW were correlated with the level of ferritin, independent risk factors were TTV (range 1,961\u201330,090\u2009ml in patients with hyperferritinemia, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and BSA change from the time of diagnosis to the time of ferritin check (range \u22120.15 to 0.31\u2009m<jats:sup>2<\/jats:sup> in patients with hyperferritinemia, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Increase in BSA was correlated with reduction of hyperferritinemia in follow\u2010up ferritin measurements (<jats:italic>P<\/jats:italic>\u2009=\u20090.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to TTV, change in BSA is an independent predictor for the degree and possibly persistence of hyperferritinemia in pediatric cancer patients and should be considered in decisions to initiate interventions. Pediatr Blood Cancer 2013;60:1671\u20131675. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24629","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T13:00:07Z","timestamp":1371474007000},"page":"1671-1675","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for hyperferritinemia secondary to red blood cell transfusions in pediatric cancer patients"],"prefix":"10.1002","volume":"60","author":[{"given":"Ali","family":"Amid","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Barrowman","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute, Clinical Research Unit University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abi","family":"Vijenthira","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Lesser","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Mandel","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveena","family":"Ramphal","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412607"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0051-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03195.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00842.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90264-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-054924"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060828.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199908)61:4<262::AID-AJH7>3.0.CO;2-B"},{"key":"e_1_2_6_10_1","first-page":"63","article-title":"Iron overload and liver dysfunction after allogeneic or autologous bone marrow transplantation","volume":"17","author":"McKay PJ","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.10.853"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200002000-00001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21260"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22851"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.91"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24046"},{"key":"e_1_2_6_17_1","first-page":"363","article-title":"Prevalence of iron overload in pediatric oncology patients after blood transfusion","volume":"10","author":"Gurram MK","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0700215"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90059-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390701"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310903"},{"key":"e_1_2_6_22_1","volume-title":"Cancer incidence, survival among children, adolescents: United States SEER Program 1975\u20131995","author":"Ries LAG"},{"key":"e_1_2_6_23_1","volume-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2012"},{"key":"e_1_2_6_24_1","unstructured":"ReddyK EngJ CarlsonCA et al.Iron overload in childhood cancer survivors. 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