{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:14:58Z","timestamp":1771488898131,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["K24"],"award-info":[{"award-number":["K24"]}]},{"name":"NIH","award":["DK076808"],"award-info":[{"award-number":["DK076808"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Blood Cancer"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1002\/pbc.24667","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T09:08:04Z","timestamp":1372756084000},"page":"1766-1771","source":"Crossref","is-referenced-by-count":24,"title":["Childhood cancer survivors exposed to total body irradiation are at significant risk for slipped capital femoral epiphysis during recombinant growth hormone therapy"],"prefix":"10.1002","volume":"60","author":[{"given":"Sogol","family":"Mostoufi-Moab","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Isaacoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Division of Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Gruccio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill P.","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Hobbie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"},{"name":"The University of Pennsylvania School of Nursing; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Shults","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"},{"name":"Department of Biostatistics and Epidemiology; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children's Hospital of Philadelphia; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"},{"name":"Department of Biostatistics and Epidemiology; The University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"10.1002\/pbc.24667-BIB0001|pbc24667-cit-0001","first-page":"2135","article-title":"Slipped capital femoral epiphysis","volume":"57","author":"Loder","year":"1998","journal-title":"Am Fam Physician"},{"key":"10.1002\/pbc.24667-BIB0002|pbc24667-cit-0002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/MOP.0b013e328320acea","article-title":"Slipped capital femoral epiphysis update","volume":"21","author":"Gholve","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"10.1002\/pbc.24667-BIB0003|pbc24667-cit-0003","first-page":"258","article-title":"Slipped capital femoral epiphysis: Diagnosis and management","volume":"82","author":"Peck","year":"2010","journal-title":"Am Fam Physician"},{"key":"10.1002\/pbc.24667-BIB0004|pbc24667-cit-0004","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/01.bpo.0000217718.10728.70","article-title":"The epidemiology of slipped capital femoral epiphysis: An update","volume":"26","author":"Lehmann","year":"2006","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0005|pbc24667-cit-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/BPB.0b013e328010b73d","article-title":"Potential influence of hormones in the development of slipped capital femoral epiphysis: A preliminary study","volume":"16","author":"Papavasiliou","year":"2007","journal-title":"J Pediatr Orthop B"},{"key":"10.1002\/pbc.24667-BIB0006|pbc24667-cit-0006","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00431-012-1743-3","article-title":"Silent slipped capital femoral epiphysis in overweight and obese children and adolescents","volume":"171","author":"Wabitsch","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1002\/pbc.24667-BIB0007|pbc24667-cit-0007","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/BPO.0b013e3181d076b6","article-title":"Valgus slipped capital femoral epiphysis: Prevalence, presentation, and treatment options","volume":"30","author":"Shank","year":"2010","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0008|pbc24667-cit-0008","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00432-011-1004-2","article-title":"Endocrine late effects after total body irradiation in patients who received hematopoietic cell transplantation during childhood: A retrospective study from a single institution","volume":"137","author":"Felicetti","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1002\/pbc.24667-BIB0009|pbc24667-cit-0009","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/pbc.24198","article-title":"Differential effects of radiotherapy on growth and endocrine function among acute leukemia survivors: A childhood cancer survivor study report","volume":"60","author":"Chow","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1002\/pbc.24667-BIB0010|pbc24667-cit-0010","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/bmt.2011.139","article-title":"Growth hormone treatment impact on growth rate and final height of patients who received HSCT with TBI or\/and cranial irradiation in childhood: A report from the French Leukaemia long-term follow-up study (LEA)","volume":"47","author":"Isfan","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1002\/pbc.24667-BIB0011|pbc24667-cit-0011","first-page":"41","article-title":"Headache, idiopathic intracranial hypertension, and slipped capital femoral epiphysis during growth hormone treatment: A safety update from the KIGS database","volume":"68","author":"Darendeliler","year":"2007","journal-title":"Horm Res"},{"key":"10.1002\/pbc.24667-BIB0012|pbc24667-cit-0012","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00004694-199809000-00015","article-title":"Slipped capital femoral epiphysis associated with radiation therapy","volume":"18","author":"Loder","year":"1998","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0013|pbc24667-cit-0013","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1148\/radiology.191.1.8134578","article-title":"Radiation-induced bone abnormalities after bone marrow transplantation for childhood leukemia","volume":"191","author":"Fletcher","year":"1994","journal-title":"Radiology"},{"key":"10.1002\/pbc.24667-BIB0014|pbc24667-cit-0014","first-page":"372","article-title":"Pinning in slipped capital femoral epiphysis: Long-term follow-up study","volume":"12","author":"Boero","year":"2003","journal-title":"J Pediatr Orthop B"},{"key":"10.1002\/pbc.24667-BIB0015|pbc24667-cit-0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/jc.2009-0178","article-title":"Long-term safety of recombinant human growth hormone in children","volume":"95","author":"Bell","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/pbc.24667-BIB0016|pbc24667-cit-0016","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1302\/0301-620X.56B4.703","article-title":"Slipped femoral capital epiphysis occurring during growth hormone therapy. Report of a case","volume":"56-B","author":"Rennie","year":"1974","journal-title":"J Bone Joint Surg Br"},{"key":"10.1002\/pbc.24667-BIB0017|pbc24667-cit-0017","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.2106\/00004623-197456080-00026","article-title":"Slipped upper femoral epiphysis following treatment with human growth hormone","volume":"56","author":"Fidler","year":"1974","journal-title":"J Bone Joint Surg Am"},{"key":"10.1002\/pbc.24667-BIB0018|pbc24667-cit-0018","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0022-3476(05)80647-X","article-title":"Growth hormone treatment in the United States: Demographic and diagnostic features of 2331 children","volume":"116","author":"August","year":"1990","journal-title":"J Pediatr"},{"key":"10.1002\/pbc.24667-BIB0019|pbc24667-cit-0019","first-page":"1704","article-title":"Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National cooperative growth study experience","volume":"81","author":"Blethen","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/pbc.24667-BIB0020|pbc24667-cit-0020","first-page":"1035","article-title":"Growth hormone safety update from the National cooperative growth study","volume":"13","author":"Maneatis","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1002\/pbc.24667-BIB0021|pbc24667-cit-0021","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1210\/jc.2004-2513","article-title":"Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature","volume":"90","author":"Kemp","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/pbc.24667-BIB0022|pbc24667-cit-0022","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1210\/jc.2007-1723","article-title":"Long-term safety of recombinant human growth hormone in turner syndrome","volume":"93","author":"Bolar","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/pbc.24667-BIB0023|pbc24667-cit-0023","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/BPB.0b013e32833ed967","article-title":"Orthopedic complications related to growth hormone therapy in a pediatric population","volume":"20","author":"Haidar","year":"2011","journal-title":"J Pediatr Orthop Part B"},{"key":"10.1002\/pbc.24667-BIB0024|pbc24667-cit-0024","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1067\/mpd.2003.189","article-title":"Adverse events with rhGH treatment of patients with chronic renal insufficiency and end-stage renal disease","volume":"142","author":"Fine","year":"2003","journal-title":"J Pediatr"},{"key":"10.1002\/pbc.24667-BIB0025|pbc24667-cit-0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1302\/0301-620X.32B1.5","article-title":"The endocrine basis for slipping of the upper femoral epiphysis. An experimental study","volume":"32-B","author":"Harris","year":"1950","journal-title":"J Bone Joint Surg"},{"key":"10.1002\/pbc.24667-BIB0026|pbc24667-cit-0026","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1054\/ghir.2000.0175","article-title":"Safety issues in children and adolescents during growth hormone therapy-A review","volume":"10","author":"Clayton","year":"2000","journal-title":"Growth Horm IGF Res"},{"key":"10.1002\/pbc.24667-BIB0027|pbc24667-cit-0027","first-page":"497","article-title":"Effects of exogenous growth hormone on growth plate cartilage in rats","volume":"141","author":"Rappaport","year":"1987","journal-title":"Am J Dis Child"},{"key":"10.1002\/pbc.24667-BIB0028|pbc24667-cit-0028","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/1097-0142(197908)44:2<480::AID-CNCR2820440216>3.0.CO;2-A","article-title":"Slipped capital femoral epiphysis (SCFE) following pelvic irradiation for rhabdomyosarcoma","volume":"44","author":"Dickerman","year":"1979","journal-title":"Cancer"},{"key":"10.1002\/pbc.24667-BIB0029|pbc24667-cit-0029","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jso.2930360110","article-title":"Postradiation slipped capital femoral epiphyses (SCFE)","volume":"36","author":"Sabio","year":"1987","journal-title":"J Surg Oncol"},{"key":"10.1002\/pbc.24667-BIB0030|pbc24667-cit-0030","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/1097-0142(196810)22:4<767::AID-CNCR2820220412>3.0.CO;2-7","article-title":"Clinical radiation pathology as applied to curative radiotherapy","volume":"22","author":"Rubin","year":"1968","journal-title":"Cancer"},{"key":"10.1002\/pbc.24667-BIB0031|pbc24667-cit-0031","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/mpo.2950060402","article-title":"Slipped capital femoral epiphysis following radiotherapy and chemotherapy","volume":"6","author":"Ryan","year":"1979","journal-title":"Med Paediatr Oncol"},{"key":"10.1002\/pbc.24667-BIB0032|pbc24667-cit-0032","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01241398-198505000-00002","article-title":"Slipped capital femoral epiphysis following radiotherapy","volume":"5","author":"Barrett","year":"1985","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0033|pbc24667-cit-0033","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1542\/peds.51.6.1042","article-title":"Epidemiology of slipped capital femoral epiphysis: A review of the literature","volume":"51","author":"Kelsey","year":"1973","journal-title":"Pediatrics"},{"key":"10.1002\/pbc.24667-BIB0034|pbc24667-cit-0034","first-page":"97","article-title":"Demographic predictors of severity of stable slipped capital femoral epiphyses","volume":"88","author":"Loder","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1002\/pbc.24667-BIB0035|pbc24667-cit-0035","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/01.bpo.0000184651.34475.8e","article-title":"Relationship between body mass index and slipped capital femoral epiphysis","volume":"25","author":"Mannof","year":"2005","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0036|pbc24667-cit-0036","first-page":"369","article-title":"Body mass index and slipped capital femoral epiphysis","volume":"12","author":"Poussa","year":"2003","journal-title":"J Pediatr Orthop Part B"},{"key":"10.1002\/pbc.24667-BIB0037|pbc24667-cit-0037","first-page":"869","article-title":"Die entstehung von coxa valga durch epiphysenverschiebung","volume":"28","author":"Muller","year":"1926","journal-title":"Beitr Klin Chir"},{"key":"10.1002\/pbc.24667-BIB0038|pbc24667-cit-0038","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/01.bpo.0000230331.96157.14","article-title":"Valgus slipped capital femoral epiphysis","volume":"26","author":"Loder","year":"2006","journal-title":"J Pediatr Orthop"},{"key":"10.1002\/pbc.24667-BIB0039|pbc24667-cit-0039","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/BPB.0b013e328346d2ec","article-title":"Valgus slipped capital femoral epiphysis: Report of two cases and a comprehensive review of literature","volume":"20","author":"Venkatadass","year":"2011","journal-title":"J Pediatr Orthop Part B"},{"key":"10.1002\/pbc.24667-BIB0040|pbc24667-cit-0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2106\/00004623-195234010-00033","article-title":"Slipped capital femoral epiphysis; early diagnosis; and treatment facilitated by normal roentgenograms","volume":"34-A","author":"Klein","year":"1952","journal-title":"J Bone Joint Surg Am"},{"key":"10.1002\/pbc.24667-BIB0041|pbc24667-cit-0041","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00003086-199601000-00011","article-title":"Valgus slipped capital femoral epiphysis. Fact or fiction","volume":"322","author":"Segal","year":"1996","journal-title":"Clin Orthop Relat Res"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pbc.24667\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:49:06Z","timestamp":1645922946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24667"}},"subtitle":["SCFE Risk in Cancer Survivors on rhGH"],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"URL":"https:\/\/doi.org\/10.1002\/pbc.24667","archive":["Portico"],"relation":{},"ISSN":["1545-5009"],"issn-type":[{"value":"1545-5009","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7,2]]}}}