{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:16Z","timestamp":1791346636367,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kuwait University Research Administration","award":["MK01\/08"],"award-info":[{"award-number":["MK01\/08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objective<\/jats:title><jats:p>While overt stroke and silent brain infarcts (SBI) are uncommon among Kuwaiti patients with sickle cell disease (SCD), there have been no previous transcranial Doppler (TCD) studies in this population. The main objective of this study is to determine TCD velocities in a group of Kuwaiti children with SCD and correlate same with brain magnetic resonance imaging (MRI) and angiography (MRA) findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010three steady\u2010state, pediatric patients with SCD aged 10.1\u2009\u00b1\u20093.9 years (21 SS, 19 S\u03b2<jats:sup>0<\/jats:sup>Thal, and 3 SD) were studied. Twenty\u2010six age\u2010matched, normal siblings of the patients served as controls. TCD was performed using a General Electric (GE), Vivid 3 equipment and MRI\/MRA with a GE Signa Excite HD 1.5 Tesla magnet. Complete blood count was with an electronic counter and Hb quantitation with cation\u2010exchange high performance liquid chromatography (HPLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean time\u2010averaged mean of the maximum velocity (TAMV) was significantly higher in the SCD group than the controls, but was normal (&lt;170\u2009cm\/second) in all. The mean values were comparable among the SS and S\u03b2<jats:sup>0<\/jats:sup>thal groups. Five (11.1%) patients had SBI and all were between 12 and 16 years of age. There was no significant difference of TAMV in this group compared to those without infarcts. No patient showed evidence of stenosis or any other abnormalities in the circle of Willis vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mild phenotype among Kuwaiti patients with SCD is reflected in normal TCD velocities and a low prevalence of SBI in children with the disease. Pediatr Blood Cancer 2014;61:25\u201328. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24758","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T09:10:05Z","timestamp":1378717805000},"page":"25-28","source":"Crossref","is-referenced-by-count":16,"title":["Transcranial doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels"],"prefix":"10.1002","volume":"61","author":[{"given":"Akram","family":"Asbeutah","sequence":"first","affiliation":[{"name":"Faculty of Allied Health Sciences, Department of Radiologic Sciences Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Radiology Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Al\u2010Saeid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Radiology Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Ashebu","sequence":"additional","affiliation":[{"name":"Department of Radiology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundus","family":"Al\u2010Sharida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mullah\u2010Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada Yousef","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adekunle","family":"Adekile","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2009.10"},{"key":"e_1_2_6_3_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: Rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.07.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.640"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102151"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203753"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10143"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10376"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0050-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(86)90016-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500511"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(97)00099-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00063.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-1419-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23152"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07660.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59565-2.00064-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.81540"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143891"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06894.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.214.145"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046529"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199609)53:1<1::AID-AJH1>3.0.CO;2-V"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2791"},{"key":"e_1_2_6_26_1","first-page":"23","article-title":"Sickle cell disease in the post genomic era: A monogenic disease with a polygenic phenotype","volume":"2009","author":"Driss A","year":"2009","journal-title":"Genomics Insights"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-464156"}],"container-title":["Pediatric Blood &amp; 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