{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:22:37Z","timestamp":1774326157563,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim was to study risk\u2010factors for vascular thrombosis and incidence of pulmonary artery hypertension (PAH) in splenectomized children with hereditary spherocytosis (HS) at a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Pre\u2010 and post\u2010splenectomy hemoglobin and platelet counts were recorded. Post\u2010splenectomy lipid\u2010profile, fibrinogen, D\u2010dimer, CRP and anti\u2010coagulant\u2010protein levels were compared to established controls. Echo\u2010Doppler was performed for PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six children with HS had undergone splenectomy; the mean age at surgery was 7.9\u2009\u00b1\u20093.7 years. Nineteen of the 26 were prospectively investigated at a median duration of 4.5 years (range: 4 months to 19 years) following splenectomy. Thrombocytosis was observed in 19 (73%), whereas no patient had erythrocytosis at the last follow\u2010up visit. Total cholesterol, LDL\u2010C, HDL\u2010C, and triglyceride levels were not deranged (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.3). Mean CRP levels (males: 2.8\u2009\u00b1\u20090.5; females: 2.1\u2009\u00b1\u20090.5\u2009mg\/L) were significantly higher than described for normal children (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Six (23%) patients had a positive D\u2010dimer assay. Protein S, anti\u2010thrombin\u2010III and fibrinogen were in range. A single patient had a borderline low protein C activity. Lupus anticoagulant and anti\u2010cardiolipin antibody assays were negative. The mean tricuspid regurgitant jet velocity (TRJV) was 1.8\u2009\u00b1\u20090.55\u2009meter per second (range: 0\u20132.4). None had a TRJV \u22652.5\u2009meter per second to suggest PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no evidence of PAH, dyslipidemia, elevation of fibrinogen or a reduction in anti\u2010coagulant proteins, at a median follow\u2010up duration of 4.5 years following splenectomy in children with HS. However, elevated CRP level (42%), persistent thrombocytosis (73%) and elevated D\u2010dimer levels (23%) were observed. These have been recognized as risk factors for cerebrovascular and coronary heart disease. Pediatr Blood Cancer 2014;61:29\u201333. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24766","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T16:08:57Z","timestamp":1379088537000},"page":"29-33","source":"Crossref","is-referenced-by-count":30,"title":["Risk factors for thromboembolism and pulmonary artery hypertension following splenectomy in children with hereditary spherocytosis"],"prefix":"10.1002","volume":"61","author":[{"given":"Anirban","family":"Das","sequence":"first","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit Department of Pediatrics Advanced Pediatrics Center Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Bansal","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit Department of Pediatrics Advanced Pediatrics Center Chandigarh 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India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Trehan","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit Department of Pediatrics Advanced Pediatrics Center Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram K.","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit Department of Pediatrics Advanced Pediatrics Center Chandigarh 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