{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:09:20Z","timestamp":1788786560681,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>We report two cases of high\u2010risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but also in <jats:italic>MYCN<\/jats:italic> amplification and <jats:italic>HA\u2010RAS\/TRKA<\/jats:italic> immunoreactivity (Case 1), anaplastic lymphoma kinase (ALK) immunoreactivity (Case 2). These two cases with multiple separated components were similar to cases classified as ganglioneuroblastoma, nodular subtype (GNBn), in terms of composite tumor. Comparable to the GNBn category, the prognosis of the patients described here may depend on the components with unfavorable histology according to International Neuroblastoma Pathology Classification. Further analyses of such composite neuroblastoma cases are important for assessing disease prognosis. Pediatr Blood Cancer 2014;61:760\u2013762. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24779","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:57:16Z","timestamp":1381528636000},"page":"760-762","source":"Crossref","is-referenced-by-count":3,"title":["Two cases of neuroblastoma comprising two distinct clones"],"prefix":"10.1002","volume":"61","author":[{"given":"Fumito","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology National Medical Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Osumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Keio University, School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"National Hospital Organization Hiroshimanishi Medical Center Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nakagawara","sequence":"additional","affiliation":[{"name":"Department Division of Biochemistry Chiba Cancer Center Research Institute Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<349::AID-CNCR20>3.0.CO;2-Y"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01681.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2350\/06-06-0117.1"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.02.016"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.12.003"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4419"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<1150::AID-CNCR25>3.0.CO;2-7"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11773"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(20010101)36:1<1::AID-MPO1002>3.0.CO;2-L"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000202163.82525.5c"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:01:58Z","timestamp":1696521718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,20]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/pbc.24779"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24779","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,20]]}}}