{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:21:09Z","timestamp":1766157669340},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>Vitamin B12 deficiency is rare in children, with nonspecific symptoms including failure to thrive, vomiting, anorexia, and neurologic changes with or without hematologic disturbances. The neuropathy can be severe and irreversible. We report four cases of children with B12 deficiency secondary to adult type pernicious anemia, a presumed transport protein abnormality, and a metabolic defect. All demonstrated neurologic compromise that improved after initiation of B12 therapy. Hematologic manifestations may be preceded by constitutional, gastrointestinal, or neurologic changes, and must raise concern for B12 deficiency. Therapy should be initiated promptly in this setting to prevent irreversible neuropathy. Pediatr Blood Cancer 2014;61:753\u2013755. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24784","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:01:37Z","timestamp":1381539697000},"page":"753-755","source":"Crossref","is-referenced-by-count":20,"title":["Vitamin B12 deficiency: The great masquerader"],"prefix":"10.1002","volume":"61","author":[{"given":"Sarah","family":"Dobrozsi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Medical College of Wisconsin\/Children's Research Institute of the Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica H.","family":"Flood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Medical College of Wisconsin\/Children's Research Institute of the Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Panepinto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Medical College of Wisconsin\/Children's Research Institute of the Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Paul","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Medical College of Wisconsin\/Children's Research Institute of the Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Brandow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Medical College of Wisconsin\/Children's Research Institute of the Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1641"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.6.575"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1182\/blood.V76.5.871.871","article-title":"Clinical spectrum and diagnosis of cobalamin deficiency [see comments]","volume":"76","author":"Stabler S","year":"1990","journal-title":"Blood"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112160"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199107000-00001"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197809000-00001"},{"key":"e_1_2_4_8_1","volume-title":"Hematology basic principles and practice","author":"Hoffman R","year":"2005"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61041-6"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.15057"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1001\/archinte.1988.00380080016007","article-title":"Pernicious anemia: The expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking","volume":"148","author":"Carmel R","year":"1988","journal-title":"Arch Intern Med"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1542\/peds.8.1.88","article-title":"Juvenile pernicious anemia","volume":"8","author":"Reisner EH","year":"1951","journal-title":"Pediatrics"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90149-X"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30288"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24784","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:03:02Z","timestamp":1696521782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,21]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/pbc.24784"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24784","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,21]]}}}