{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:49:25Z","timestamp":1780588165404,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective cohort study analysed the clinical characteristics and outcomes of patients with childhood lymphoblastic lymphoma (LBL) treated in Shanghai, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>From 2001 to 2010, 108 evaluable patients \u226416 years of age who were newly diagnosed with biopsy\u2010proven LBL were treated with one of three treatment protocols: CCCG\u201099, SCMC\u2010T\u2010NHL\u20102002, or LBL\u2010CHOF\u20102006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients had Stage I disease, 5 had Stage II, 55 had Stage III, and 46 had Stage IV. The immunophenotype was T\u2010cell LBL in 92 patients (85.2%) and precursor B\u2010cell LBL in 16 (14.8%). The abandonment rate was 11.5%. Twenty\u2010five patients (23.2%) suffered from resistant disease, including 1 with isolated central nervous system (CNS) relapse. At a median follow\u2010up of 40.4 months (range, 0\u2013114 months), the 5\u2010year probability of event\u2010free survival (pEFS) was 63.9\u2009\u00b1\u20094.6% in all patients. The 5\u2010year pEFS for patients with pB\u2010LBL was better than for patients with T\u2010LBL (100% vs. 61.3\u2009\u00b1\u20095.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Patients who had achieved complete remission on day 33 of induction had significantly better pEFS than those who had not (78.8\u2009\u00b1\u20094.6% vs. 28.2\u2009\u00b1\u20099.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). Three of 25 patients who experienced resistant disease were alive at the end of the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The abandonment rate was lower for patients with LBL than for patients with acute lymphoblastic leukemia. Prophylactic cranial radiation can be omitted for patients with LBL even when advanced\u2010stage disease is present, as intensive systemic chemotherapy with intrathecal therapy is sufficient to prevent CNS relapse. The survival of patients with resistant disease was very poor. Pediatr Blood Cancer 2014;61:659\u2013663. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24848","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T21:40:01Z","timestamp":1384465201000},"page":"659-663","source":"Crossref","is-referenced-by-count":18,"title":["Clinical outcome of childhood lymphoblastic lymphoma in Shanghai China 2001\u20132010"],"prefix":"10.1002","volume":"61","author":[{"given":"Yi\u2010Jin","family":"Gao","sequence":"first","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci","family":"Pan","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Juan","family":"Lu","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Liang","family":"Xue","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Dong","family":"Ye","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Miao","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wen","family":"Qian","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Hua","family":"Meng","sequence":"additional","affiliation":[{"name":"Children's Hospital Shanghai Medical College, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24416"},{"key":"e_1_2_5_3_1","first-page":"759","article-title":"Treatment results of XinHua T\u2010NHL\u201097 in children with advanced T\u2010cell non\u2010Hodgkin lymphoma: Reports from Shanghai Children's Medical Center [in Chinese]","volume":"40","author":"Tang JY","year":"2002","journal-title":"Zhong Hua Er Ke Za Zhi"},{"key":"e_1_2_5_4_1","first-page":"814","article-title":"The clinical study on the treatment of III\/IV stage T\u2010NHL using CCCG regimen [in Chinese]","volume":"32","author":"Li Z","year":"2005","journal-title":"Zhong Guo Zhong Liu Lin Chuang"},{"key":"e_1_2_5_5_1","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: A BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.2.186"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1031"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22162"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292615"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21629"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.07.004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31802d3e7a"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701784730"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22127"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12122"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.2707"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.011"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.400"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08541.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9147-4"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990615)85:12<2648::AID-CNCR22>3.0.CO;2-R"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.3367"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24848","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.24848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.24848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:03:33Z","timestamp":1696521813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.24848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/pbc.24848"],"URL":"https:\/\/doi.org\/10.1002\/pbc.24848","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}