{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:59:00Z","timestamp":1715601540047},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Hemophilia Foundation\/Baxter Clinical Research Fellowship Award"},{"name":"The ASH Scholar Award"},{"name":"The Hemostasis and Thrombosis Research Society Mentored Research Award"},{"name":"The CSL Behring:Prof. Heimburger Award in Hemostasis"},{"name":"The NIH","award":["K12 HD068372-03"],"award-info":[{"award-number":["K12 HD068372-03"]}]},{"name":"Child Health Research Career Development Award"},{"name":"NIH","award":["RO1 HL084086-01"],"award-info":[{"award-number":["RO1 HL084086-01"]}]},{"name":"The Postle Family Chair of Pediatric Cancer and Blood Disorders"},{"name":"CDC","award":["1U27DD00862-01"],"award-info":[{"award-number":["1U27DD00862-01"]}]},{"name":"MCHB\/HRSA","award":["5 H30MC00008-20-00"],"award-info":[{"award-number":["5 H30MC00008-20-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:label \/><jats:p>Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C\/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold\u2010based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population. Pediatr Blood Cancer 2014;61:936\u2013939. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24860","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T15:56:28Z","timestamp":1385481388000},"page":"936-939","source":"Crossref","is-referenced-by-count":5,"title":["FVIII\/VWF ratio is not a reliable predictor of VWD in children"],"prefix":"10.1002","volume":"61","author":[{"given":"Brian R.","family":"Branchford","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Hematology\/Oncology\/Bone Marrow Transplantation at The Children's Hospital Colorado and University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ruegg","sequence":"additional","affiliation":[{"name":"Hemophilia &amp; Thrombosis Center Research Laboratory University of Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Villalobos\u2010Menuey","sequence":"additional","affiliation":[{"name":"Hemophilia &amp; Thrombosis Center Research Laboratory University of Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda J.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Hemophilia &amp; Thrombosis Center Research Laboratory University of Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Hematology\/Oncology\/Bone Marrow Transplantation at The Children's Hospital Colorado and University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Manco\u2010Johnson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Hematology\/Oncology\/Bone Marrow Transplantation at The Children's Hospital Colorado and University of Colorado Anschutz Medical Campus Aurora Colorado"},{"name":"Hemophilia &amp; 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